平降颗粒联合尼群地平对自发性高血压大鼠血管活性肽的影响

Influence of Pingjiang Granule Combined with Nitrendipine on Vascoactive Peptides in Spontaneous Hypertensive Rats (SHR)

关键词:  平降颗粒  尼群地平  自发性高血压大鼠  降钙素基因相关肽  内皮素

Key words:  Pingjiang granule  Nitrendipine  SHR  CGRP  ET

摘要:

目的:探讨平降颗粒与尼群地平联合降压的机制以及保护靶器官,防治高血压并发症的问题。方法:采用放射免疫分析法测定经中西药联用4周后自发性高血压大鼠(SHR)组织及血浆降钙素基因相关肽(CGRP)及血浆内皮素(ET)的浓度,并与对照组比较。结果:用药的3组CGRP含量在血浆中高于常水组,而在下丘脑和腹主动脉则低于常水组,均具有统计学意义,其中中西结合组与中、西药组分别比较又有显着性差异;用药3组血浆ET含量均低于常水组,均具有统计学意义,其中中西结合组血浆ET含量更低,与中、西药组分别比较均有显着性差异。结论:调控循环血中血管活性肽CGRP和ET是平降颗粒和尼群地平降压机理之一,也是其保护靶器官,防治高血压并发症的重要机制,此两药联合使用作用明显优于单用

Abstract:

Objective: To investigate the antihypertensive mechanism of Pingjiang Granule combined with Nitrendipine, protective effect for target organ, preventive and curative effect against hypertension complication. Methods: After four weeks of medicine, the concentration of calcitonin gene relative peptide(CGRP) in tissue, plasma and plasma endothelin (ET) level were examinated with radio-immunity assay in SHR,and compared with those in control group. Results: Plasma CGRP was higher in three treatment groups than in control group, while in hypothalamus and abdominal aortic artery was lower with statistic significance. Significant difference also existed between combined medicine group and western medicine group, Chinese medicine group separately.Plasma ET in three treatment groups was all lower than in control group and had statistic significance with the lowest value in combined group. Conclusion: Regulating and controlling the concentration of CGRP and ET in circulatory system are one of the mechanisms of antihypertensive effect of combined medicine, as well as the main mechanism of protecting target organs, and preventing and curing hypertension complication. The effect of combined medicine is markedly superior to that of single medicine.