调脂化瘀方对冠心病高脂血症患者血浆内皮素及胰岛素抵抗的影响

Influence of Tiaozhi Huayu Fang on the Resistance of Plasma Endothelina and Insulin in Patients with Coronary Heart Disease Accompanied with Hyperlipemia

关键词:  冠心病  高脂血症  内皮素  胰岛素抵抗  调脂化瘀

Key words:  coronary heart disease  hyperlipemia  endothelin  the resistence of insulin  Tiaozhi Huayu

摘要:

目的: 探讨调脂化瘀方对冠心病伴高脂血症患者血浆内皮素及胰岛素抵抗的影响。方法: 选择冠心病血脂异常增高患者30例作为观察组,并以健康成人17例作为对照组。观察组予调脂化瘀方,1剂/d,水煎分3次口服,3周为1个疗程,间歇1周,共4个疗程。所有观察对象于治疗前后同步检测血清总胆固醇(TC)、血清甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血浆内皮素(ET)、胰岛素敏感指数(ISI)、空腹血胰岛素水平(FINS)、体重指数(BMI)。结果: 1)两组血脂各项比较有显著性差异(P<0.05,P<0.01),观察组血脂各项治疗前后比较有显著性差异(P<0.05)。2)两组ET、FINS、ISI比较有显著性差异(均P<0.05),观察组治疗前后ET、ISI比较有显著性差异(均P<0.05)。结论: 调脂化瘀方治疗冠心病伴高血脂患者,可通过降低患者的血脂水平,改善血管内皮功能,减低内皮素释放,缓解患者的胰岛素抵抗。

Abstract:

Objective: To study the influene of Tiaozhi Huayu Fang on the resistance of plasma endothelin and insulin in patients with coronary heart disease accompanied with hyperlipemia. Methods: There were 2 groups: treatment group(30 cases with hyperlipemia)and control group(17 healthy volunteers).Tiaozhi Huayu Fang was given to the patients in treatment group.7 indexes including Tc(total cholesterol),TG(triglyceride),LDL_C(high_density liprotein),LDL_D(low_density lipoprotein),ET(endothelin),FINS(fasting insulin),BMI(body mass index)and ISI(insulin sensitive index)were tested before and after treatment simultaneously in both groups.Results: 1)There was an obvious difference between these two groups(P<0.05,P<0.01).And in treatment group,there was also a marked difference before and after treatment (P<0.05).2)There was an obvious differenec of ET,FINS,ISI,between both groups(P<0.05).And there was an obvious difference of ET,ISI in treatment group before and after treatment(P<0.05). Conclusion: Therapeutic effect of Tiaozhi Huayu Fang on patients with coronary heart disease accompanied with hyperlipemia can be established by lowering blood_lipid,improving vascular endothelial function,decreasing endothelin releasing and improving the resistence to insulin.