仁术健胃颗粒对慢性萎缩性胃炎患者幽门螺杆菌及其cagA基因的影响

Influence of Renzhu Jianwei Granule on Helicobacter Pyloric (Hp) and its gene cagA in cases with chronic atrophic gastritis

关键词:  仁术健胃颗粒  慢性萎缩性胃炎  幽门螺杆菌  cagA基因  实验研究

Key words:  Renzhu Jianwei Granule  chronic atrophic gastritis  Helicobacter Pyloric (Hp)  cagA gene  experiment research

摘要:

[目的]观察仁术健胃颗粒对慢性萎缩性胃炎(CAG)患者幽门螺杆菌(Hp)及Hp-cagA基因的影响,进一步探讨其治疗机制。[方法]选择符合CAG伴Hp感染气虚热郁证的患者共128例,随机分为治疗组85例,cagA阳性者53例;对照组43例,cagA阳性者29例。治疗组予仁术健胃颗粒1包,冲服,3次/d,对照组予胃复春4片,口服,3次/d.观察治疗前后临床症状、胃镜征象、病理、Hp及Hp-cagA基因的变化。[结果]治疗组临床、胃镜、病理有效率分别为91.8%、71.8%、65.9%,对照组分别为86.0%、55.8%、41.7%,治疗组胃镜、病理有效率高于对照组,有统计学意义(P<0.05);治疗组Hp的根除率、有效率分别为36 5%(31/85)、77 6%(66/85),对照组为30.2%(13/43)、69.8%(30/43),无统计学意义(P>0.05);但治疗组Hp-cagA基因阴转率(64.2%,34/53)高于对照组(41.4%,12/29),有统计学意义(P<0.05).[结论]仁术健胃颗粒对CAG有一定的治疗作用,其作用机制可能与根除Hp,减轻、削弱Hp毒力有关。

Abstract:

[Objective] To observe the influence of Renzhu Jianwei Granule on Helicobacter Pyloric (Hp) and its gene cagA in cases with chronic atrophic gastritis (CAG) and study the therapeutic mechanism intensively.[Methods] One hundred and twenty-eight CAG cases with Hp infection and belonging to qi deficiency and heat stagnation type were divided into treatment group (85 cases, given Renzhu Jianwei Granule with 1 bag, three times a day) and control group (43 cases, given Weifuchun Tablet with 4 tablets, three times a day). The changes of clinical symptoms, gastroscope, pathology, Hp and Hp-cagA were observed. The effective rate in clinical symptoms, gastroscopy, pathology in treatment group were 91.8%, 71.8%, 65.9%, while in control group 86.6%, 55.8%, 41.7% respectively.[Results] The effective rate of gastroscopy and pathology in treatment group was higher than that in control group and has a statistic significance (P<0.05).The eradicative rate of Hp and effective rate were 36.5% and 77.6% in treatment group, 30.2% and 69.8% in control group respectively with no significance (P>0.05). But the Hp-cagA gene negative rate (64.2%) in treatment group was higher than that (41.4%) in control group with statistic significance(P<0.05).[Conclusion] Renzhu Jianwei Granule has a therapeutic effect on CAG. The mechanism is associated with eradication of Hp and decreasing of the virulence of Hp.