苦参素联用单磷酸阿糖腺苷治疗慢性乙型肝炎的临床研究

Clinical research on chronic hepatitis B treated by kurarinone combined with arabinosyladenosine monophosphate (Ara-Amp)

关键词:  慢性乙型肝炎  苦参素  单磷酸阿糖腺苷  联合用药

Key words:  chronic Hepatitis B  kurarinone  Ara-Amp  combination treatment

摘要:

[目的]探讨苦参素联用单磷酸阿糖腺苷治疗慢性乙型肝炎的临床效果。[方法]将152例慢性乙型肝炎随机分成联合治疗组、苦参素组、单磷酸阿糖腺苷组进行对照观察。[结果]联合治疗组在HBeAg、HBV-DNA阴转方向较单用苦参素或单磷酸阿糖腺苷效果好,治疗6个月和12个月其总有效率三组无明显差异。[结论]联合用药较单一用药效果为佳。

Abstract:

[Objective] To discuss the effect of kurarinone combined with arabinosyladenosine monophosphate (Ara-Amp) on chronic hepatitis B. [Methods] One hundred and fifty-two patients were divided into combination group, kurarinone group and Ara-Amp group. [Result] The negative turning of HbeAg, HBV-DNA in combination treatment group was superior to that in other two groups. There was no marked diffecence of the overall effective rate between these 3 groups 6 months and 12 months after treatment. [Conclusion] The combination treatment is more effective than the treatment with single medicine.