| 摘要: |
| [目的]建立水飞蓟宾卵磷脂分散体胶囊剂中水飞蓟宾的溶出度测定方法。[方法]参照中国药典2000年版二部附录XC溶出度测定第2法,用紫外-可见分光光度仪测定溶出度。[结果]确定了以pH7.8～8.0的磷酸缓冲液加0.5%聚氧乙烯十二烷基醚为溶剂进行溶出度考察。测定方法和溶出方法的验证结果表明,本方法重现性较好。[结论]该法准确,可靠,能够用于水飞蓟宾卵磷脂分散体胶囊剂的溶出度测定。 |
| 关键词: 水飞蓟宾 卵磷脂分散体 溶出度 |
| DOI：10.11656/j.issn.1672-1519.2004.01.33 |
| 分类号: |
| 基金项目: |
|
| Study on dissolution test method of Silybin Solid Dispersion Capsules |
|
REN Xiao-wen, XU Wei-ren, LIAN Xiao-yan
|
|
Tianjin Institute of Medicine, Tianjin 300193, China
|
| Abstract: |
| [Objective] To establish a method in determining the dissolution of silybin solid dispersion capsules. [Methods] According to the description in Chp.2000.VolⅡ.Appendix XC, the dissolution of silybin solid dispersion capsules was determined by UV-VIS spectrophotometer. [Results] The selected media for dissolution test is phosphate buffer solution with 0.5% Brij35 (pH7.8～8.0).The dissolution of capsules has good reproducibility. [Conclusion] The method is considered to be a accurate and reliable dissolution determination for silybin capsules. |
| Key words: silybin solid dispersion dissolution |
