| 摘要: |
| [目的]观察益心饮对病毒性心肌炎小鼠超氧化物歧化酶(SOD)及丙二醛(MDA)活性的影响。[方法]Balb/c小鼠120只均为雄性,体质量(20±2)g,随机分为6组,各组在给药后第7d和第14d分别处死8只及全部小鼠,眼眶取血制备血清,进行SOD和MDA检测。[结果]与病毒对照组相比,益心饮中剂量组、大剂量组在第7d和第14d能显著提高血浆SOD活性,降低MDA含量(P<0.01)。[结论]益心饮能减轻氧自由基对心肌膜脂质过氧化损伤反应。 |
| 关键词: 病毒性心肌炎 益心饮 超氧化物歧化酶(SOD) 丙二醛(MDA) |
| DOI：10.11656/j.issn.1672-1519.2004.03.04 |
| 分类号: |
| 基金项目:全军医药卫生科研基金课题 (01MA158) |
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| Influence of Yi Xin Drink to SOD and MDA activity in mice with viral myocarditis |
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ZHENG Pei-yong,QIN Zhi-feng,WEI Xiao
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Longhua Hospital Affiliated to Shanghai University of TCM, Shanghai, 300032, China
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| Abstract: |
| [Objective]To observe the influence of Yi Xin Drink to SOD and MDA activity in mice with viral myocarditis.[Method]One hundred and twenty male Balb/c mice,weighing(20±2)g,were randomly divided into6groups,8 mice in each group were killed after 7d and 14d medication respectively.Serum was prepared from the orbit blood sampling for the SOD and MDA detection.[Result]Comparing with virus control group,the Yi Xin Drink in middle dosage group,big dosage group could increase serum SOD activity at 7d and 14d evidently,decrease the MDA content(P<0.01).[Conclusion]The Yi Xin Drink can alleviate lipid peroxidation damage reaction of myocardial membrane induced by oxy-gen-derived free radidicals. |
| Key words: viral myocarditis Yi Xin Drink SOD MDA |
