清热化滞颗粒对大鼠胃蛋白酶活性、胃酸和小鼠肠蠕动的影响

Effect of Qingrehuazhi Granule on the digestive function in mice

关键词:  清热化滞颗粒  消化功能  胃酸  胃蛋白酶  小肠推进率

Key words:  Qingrehuazhi granule  digestive function  gastric acid  pepsin  propulsive rate of small intestine

摘要:

[目的]研究清热化滞颗粒对实验动物消化功能的影响。[方法]测定实验大鼠胃蛋白酶的活性、胃酸含量;小鼠小肠推进率。[结果]清热化滞颗粒可使胃游离酸和胃总酸分泌量增加;能提高大鼠胃蛋白酶活力,与空白对照组比较P<0.01;并对正常小鼠及盐酸阿托品负荷小鼠小肠推进功能具有促进作用,与空白对照组及药物对照组比较P<0.01。[结论]清热化滞颗粒治疗小儿积滞的作用机制可能与其有效地增加胃游离酸及总酸度,提高胃蛋白酶活性,促进胃肠蠕动,从而达到促进消化的目的有关。

Abstract:

[Objective]To observe the effect of Qingrehuazhi granule on the digestive function in experimental animal.[Methods]The activity of gastric pepsin,content of gastric acid,and the propulsive rate of intestine in rats were deter-mined.[Result]The increase of total amount of gastric acid,the free acid and the activity of gastric pepsin was higher in Qingrehuazhi granule group than that of normal group,(P<0.01).The propulsive rate of small intestine in normal mice and atropine hydrochloride loaded mice was beter than that of normal group and drug control group,(P<0.01).[Conclusion]The mechanism of the granule in treating children food retention is probably associated with effectively increasing the free and total gastric acid,raising the activity of pepsin,promoting gastrointestinal peristalsis,and finally promoting digestion.