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| 半楼贝蔹及配伍乌头对大鼠肝细胞色素P450酶含量的影响 |
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肖成荣1, 陈鹏1, 王宇光1, 谭洪玲1, 温怀青2, 高月1
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1.军事医学科学院放射医学研究所, 北京, 100850;2.西藏军区总医院, 拉萨, 850000
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| 摘要: |
| [目的]研究中药十八反中半夏、贝母、栝楼、白蔹、白及配伍乌头对大鼠肝细胞色素P450 酶含量的影响。[方法]采用紫外分光光度测定大鼠肝微粒体细胞色素P450与细胞色素b5含量。[结果]配伍组与其相应单药组比较可显著降低P450酶及b5含量(P<0.001或P<0.05)。[结论]药物配伍后导致P450酶变化,对药物的代谢产生影响。 |
| 关键词: 细胞色素P450酶 b5含量 中药十八反 |
| DOI：10.11656/j.issn.1672-1519.2004.04.24 |
| 分类号: |
| 基金项目:国家自然科学基金资助课题 (30070936) |
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| Effect of Radix Aconiti matched with pinellia,fritillaria,trichosanthes,mapelopsis, bletallae on the cytochrome P450 content of liver in rats |
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XIAO Cheng-rong,CHEN Peng,WANG Yu-guang
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Institute of Radiation Medicine, Academy of Military Medical Science, Beijing100850, China
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| Abstract: |
| [Objective] To study the effect of aconite matched with pinellia,fritillaria,trichosanthes,mapelopsis,bletallae on the content of cytochrome P450 and b5.[Method] Rat liver microsomal cytochrome P450,b5 contents were quantitated by UV chromatography.[Result] Compared with single used group,P450,b5 contents were obeviously decreased in combinative used group(p<0.001～0.05).[Conclusion] The contents of P450,b5 changed when these herbs were used together,giving effect on drug metabolism. |
| Key words: cytochrome P450 contents of b5 eighteen imcompatible pairs |
