| 摘要: |
| 芍药甘草汤 (SGT)是常用中药方剂之一,在日本临床上常和一些西药合用。甘草酸(glycyrrhizin,GL)是SGT中主要的有效配糖体成分之一,经口给药后,GL在肠道内被肠内细菌代谢成活性产物甘草次酸(18β_glycyrrheticacid,GA)。本研究旨在利用大鼠,以GA的血药浓度为指标,探讨合用西药对SGT中GL的生物利用度的影响以及减少该影响的给药方案。笔者在本部分中首先考察了SGT中GL生物利用度在SGT连续给药下的变化。实验结果显示,GL生物利用度随着SGT的连续给药而逐渐上升。 |
| 关键词: 药物相互作用 芍药甘草汤 甘草酸 药动学 |
| DOI：10.11656/j.issn.1672-1519.2004.04.38 |
| 分类号: |
| 基金项目: |
|
| Reduction of bioavailability of glycyrrhizin in Shaoyao-Gancao-Tang by co-administered antibacterial drugs and ways of minimizing it (Part I)Alteration of bioavailability of glycyrrhizin from repeated administration of Shaoyao-Gancao-Tang |
|
HE Ju-xiu1, Tadoto Tani2
|
|
1.Division of Kampo-pharmaceutics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama930-0194, Japan;21 st Century COE Program, Toyama Medical and Pharmaceutical University, Toyama930-0194, Japan
|
| Abstract: |
| Shaoyao-Gancao-Tang(SGT),a traditional Chinese prescription,is sometimes used together with some synthetic drugs in Japan.Glycyrrhizin(GL)is a major active glycoside ingredient in SGT and is biotransformed into a bioactive metabolite,18β-glycyrrhetic acid(GA),by intestinal bacteria in the gut after being orally administered.In this study,the effects of the co-administered synthetic drugs on the bioavailability of GL(plasma GA concentration)were investigated in rats.The alterations of bioavailability of GL from repetitive administration of SGT were examined.The results showed that the plasma concentration of GA was gradually elevated by the repetitive administration of GST. |
| Key words: drug-drug interaction Shaoyao-Gancao-Tang glycyrrhizin pharmacokinetics |
