| 摘要: |
| 在第I部分中,已经报告了芍药甘草汤 (SGT)的连续给药提高了SGT中甘草酸 (glycyrrhizin,GL)的生物利用度。在本文,即本研究的第II部分,对在溃疡治疗中常和SGT合用的西药,如组织胺H2 受体拮抗剂cimetidine,抗胆碱药scopolamine butyl bromide(SBB),由一个质子泵抑制剂 (omeprazole,OPZ)和两种抗菌剂(amoxicillin,AMPC,and metronidazole,MET)所组成的三剂疗法OAM等,对于SGT中GL生物利用度的影响进行了考察。实验结果显示,cimetidine或SBB的合用对SGT中GL的生物利用度没有显著影响,但OAM的合用却有显著的降低作用。OAM降低作用的要因药物经实验证明为抗菌剂组合AMPC-MET,而非质子泵抑制剂OPZ。AMPC-MET作用的原因机制在于其显著地降低了肠内细菌的将GL代谢成甘草次酸 (18β-glycyrrhetic acid,GA)的活性。该结果表明,含有AMPC-MET的三剂疗法如OAM等不适合和SGT同时给药。 |
| 关键词: 药物相互作用 芍药甘草汤 西药 甘草酸 药动学 肠内细菌 代谢活性 |
| DOI：10.11656/j.issn.1672-1519.2004.05.37 |
| 分类号: |
| 基金项目: |
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| Reduction of bioavailability of glycyrrhizin from Shaoyao-Gancao-Tang by co-administered synthetic drugs and ways of minimizing it(PartⅡ) Effects of co-administered synthetic drugs on the bioavailability of glycyrrhizin from Shaoyao-Gancao-Tang Shaoyao_Gancao_Tang |
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HE Ju-xiu1, Tadoto Tani1,2
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1.Division of Kampo-pharmaceutics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan;21st Century COE Program, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan
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| Abstract: |
| In part I,we reported that the repetitive administration of Shaoyao-Gancao-Tang(SGT)increased the bioavailability of glycyrrhizin(GL)in SGT.In clinic,SGT is sometimes used together with some synthetic drugs.In this partⅡ,the influences of co-administered synthetic drugs on the pharmacokinetic fate of GL from SGT were investigated.The results showed that the co-administration of either a histamine2-receptor antagonist(cimetidine)or an anticholinergic drug(scopolamine butyl bromide,SBB)did not clearly influence the bioavail-ability of GL in SGT.However,the co-administration of a triple therapy OAM consisting of a proton pump in-hibitor(omeprazole,OPZ)and two antibacterial drugs(amoxicillin,AMPC,and metronidazole,MET)markedly reduced the plasma GA concentration.The reduction of plasma GA by OAM was shown to be due to the an-tibacterial drugs AMPC-MET,not the proton pump inhibitor OPZ.The mechanism of the reduction by AM-PC-MET involved the severe decrease of the GL-metabolizing activity of intestinal bacteria by AMPC-MET.These results suggest that it is not appropriate to simultaneously administer AMPC-MET with SGT. |
| Key words: drug-drug interaction Shaoyao-Gancao-Tang antibacterial drugs glycyrrhizin pharmacokiˉnetics intestinal bacteria |
