化坚丸配合中医辨证论治对中晚期肿瘤患者生存质量的影响

Influence of Huajian Pills Combined with TCM Syndreme Differentiation on Existence Quality of Tumor Patients in Middle and Late Stage

关键词:  化坚丸  辨证论治  中晚期肿瘤  生存质量

Key words:  Huajian pills  TCM syndrome differentiation.  tumor

摘要:

[目的]探讨本院制剂化坚丸配合中药对中晚期恶性肿瘤患者化疗后生活质量的影响,总结化坚丸近年临床应用疗效,规范化疗中的中药应用。[方法]以住院化疗患者为研究对象,128例患者随机分为中西结合组和单纯化疗组.选取瘤体直径、karnosfky评分、体质量、临床症状、疼痛、T细胞亚群、NK细胞、血常规、肝肾功能为主要观察指标.对观察数据进行统计学分析。[结果]1)瘤体变化中西结合组有效率为79.7%,单纯化疗组有效率为69.5%,两组有效率经统计学处理有显著性差异.2)症状变化中西结合组明显高于单纯化疗组,两组比较(P<0.05).3)疼痛变化中西结合组高于单纯化疗组,但统计学处理无显著差异.4)中西结合组治疗后CD₃、CD₄、CD₄/CD₈及NK细胞活性均有不同程度的提高,与治疗前比较差异有显著性(P<0.05,P<0.01),两组治疗后比较有显著差异性(P<0.05).5)Karnofsky评分及体质量比较,中西结合组Karnofsky评分好转率为56.07%,单纯化疗组为28.81%,两组比较(P<0.05).中西结合组体质量增长好转率为44.9%(31/69),单纯化疗组好转率为32.2%(19/59),两组比较有显著性差异(P<0.05)。[结论]化坚丸服用方便,再配合临床辨证予中药汤剂,不失为提高中晚期肿瘤患者生存质量的良好治疗方法。

Abstract:

[Objective] To explore the influence of Huajian(dissipating hard mass) pills combined with Chinese herbs on life quality after chemotherapy in patients with malignancy tumor in middle or late stage,and summarize the clinical therapeutic effect in recent years,standardize the application of Chinese herbs during chemotherapy. [Methods] One hundred and twenty eight cases treated with chemotherapy in our department were randomly divided into chemotherapy only group and TCM integrated with western medicine group. Diameter of tumor body,karnosfky scale,body weight,clinical symptoms,pain,T-cell subtype,NK cell,routine blood test,liver-kidney function were adopted as the main investigated parameters. Statistically, t test was used for measure data,χ² test for count data,and rank sum test for therapeutic effect. [Results] 1) Changes of tumor body: in integrated group,complete recovery(CR)was found in 6 cases,partial regression(PR) 19 cases,no change(NC) 30 cases,the effective rate was 79.7%,while in chemotherapy only group,CR was in 2 cases,PR 13 cases,NC 26 cases,pregression of disease(PD) 18 cases,the effective rate was 69.5%. 2)Changes of symptoms:in integrated group,improvement rate was 59.42%,rate of stability was 40.58%,while that of chemotherapy group was 33.89%,50.84% respectively. The rate of improvement and stability in integrated group was apparently better than that ofchemotherapy only group,(P<0.05). 3) Changes of pain:52 cases were improved in integrated group,and the improvement rate was 92.10%; in chemotherapy group 37 cases were improved with improvement rate 71.2%. The improvement rate in integrated group was markedly better than that of chemotherapy group,there was no significant difference between these two groups. 4) Activity of CD₃,CD₄,CD₄/CD₈ and NK cell were enhanced with different degrees after chemotherapy with significant difference campared with that before treatment(P<0.05, P<0.01),there was significant difference between two groups after treatment(P<0.05). 5)Karnofsky scale and body weight:the improvement rate in integrated group was 56.07%,while in chemotherapy only group was 28.81%,(P<0.05),the improvement rate of body weight increasing in integrated group was 44.9%,while in chemotherapy only group was 32.2%(P<0.05). [Conclusion] Huajian pills is convenient to take,and is a good therapeutic method for tumor patients in middle late stage when combined with clinical TCM syndrome differentiation.