清肝化瘀汤为主治疗慢性粒细胞性白血病患者相关心理因素分析

Correlated Psychological Factors in Patients with Chronic Granulocytic Leukemia Treated Mainly by Qinggan Huayu Decoction

关键词:  慢性粒细胞性白血病  清肝化瘀汤  焦虑  抑郁

Key words:  chronic granulocytic leukemia  qinggan huayu  Anxiety  Depression

摘要:

[目的]分析清肝化瘀汤为主治疗慢性粒细胞性白血病(CML)的疗效及其对患者心理因素的影响,从心身医学角度探讨清肝化瘀汤治疗CML的疗效机制。[方法]选用焦虑自评表(SAS)、抑郁自评量表(SDS)、癌症病人生活质量量表(QLQ),指导CML患者和正常对照人员填写SAS、SDS、QLQ量表;回顾总结以清肝化瘀汤为主治疗CML患者的远期疗效。[结果]病例组与正常对照组焦虑情绪障碍发病率分别为82%和5%,抑郁情绪障碍的发病率分别为84%和5%,焦虑合并抑郁情绪障碍的发病率分别为76%和0(P<0.01),焦虑与抑郁得分与生活质量成负性相关.50例CML患者5 a生存率为76%,中位生存期74个月。[结论]CML患者存在明显的焦虑抑郁倾向,清肝化瘀汤为主治疗CML,疏肝解郁、调畅情志,整体治疗,能有效地改善CML患者心理健康状况、生存质量,延长生存期。

Abstract:

[Objective] To analyse the therapeutic effect of qinggan huayu(purging liver and eliminating stasis) decoction on patients with chronic granulocytic leukemia and the effect on its influence on psychological factors,and to discuss the mechanism of qinggan huayu decoction on CGL from the point of view of psychosomatic medicine. [Method] Self rating Anxiety Scale(SAS),Self rating Depression Scale(SDS) and Quality of Life Questionaire(QLQ) were selected to ask the CGL patients and healthy person, as control, to fill in guiding by the doctors. The long term effect of qinggan huayu decoction on CGL was reviewed and summarized. [Results] The incidence rate of anxiety were 82% and 5% in control group and treatment group respectively, the rate of depression were 84% and 5% and the rate of anxiety complicated with depression were 76% and 0(P<0.01). The score of anxiety and depression had negative correlation with quality of life. Five year survival rate of 50 CGL patients was 76%, the median intravitam was 74 months. [Conclusion] CGL patients have obvious tendency of anxiety and depression. Qinggan huayu decoction can effectively improve the psychological status and the life quality of CGL patients,and prolong the intravitam.