胃安散逆转胃癌前病变作用的临床观察

Clinical Observation on Reversal Effect of Weiansan on Precancerous Lesion of Stomach Carcinoma

关键词:  胃安散  胃癌前病变  临床观察

Key words:  Weiansan  clinical observation  precancerous lesion of stomach carcinoma

摘要:

[目的]观察胃安散对胃癌前病变患者的影响,并探讨其治疗机制。[方法]38例胃癌前病变患者,随机分为胃安散组、胃复春组,分别给予胃安散5g/次,3次/d,胃复春4片/次,3次/d,并于服药前、后分别进行胃镜检查,观察黏膜炎症情况,病理检查腺体萎缩,肠上皮化生、异型增生程度及幽门螺杆菌(Hp)感染情况;两组进行比较。[结果]胃镜所见胃安散组患者治疗后与胃复春无统计学差异(P>0.05),说明与临床公认的治疗胃癌前病变的胃复春疗效相当;而清除Hp的作用胃安散组优于胃复春组(P>0.05)。[结论]胃安散具有较好的改善临床症状及一定的抑制腺体萎缩,肠上皮化生、异型增生的作用,同时Hp有明显的清除作用。

Abstract:

[Objective] To observe the influence of Weiansan on precancerous lesion and to explore its treatment mechanism. [Methods] Thirty-eight cases were randomly divided into Weiansan group(5g, 3 times a day) and Weifuchun group. The Condition of mucosal inflammation observed by Gastroscopic examination was performed before and after treatment to observe the mucous inflammation changes. The glandular atrophy, enterocyte metaplasia,heterotypic hyperplasia degree and infection condition of helicobacter pyloric(Hp) were examined pathologically before and after administration and compared between these tow groups. [Result] There was no significant difference between these two groups in the post treatment gastroscopic examination (P>0.05),suggesting that the therapeutic effect of Weiansan is equivalent to that of Weifuchun,a known clinically effective method for treating precancerous lesion of stomach carcinoma. However, in the elimination effect of Hp action Weiansan group was better than that of Weifuchun groups(P<0.05). [Conclusion] Weiansan has better improving effect on clinical symptoms and some certain inhibitory effect on body of gland atrophy,enterocyte metaplasis,heterotypic hyperplasia,and at the same time, has an obvious effect on Hp.