扶肾降浊法对肾功能衰竭大鼠常规指标的影响

Effect of "Supporting Kidney to Eliminate Turbid Fluid" on Routine Indexes in Rats with Chronic Renal Failure

关键词:  扶肾降浊法  慢性肾功能衰竭  中医药疗法  实验研究

Key words:  Method of supporting kidney to eliminate turbid fluid"  chronic renal failure  TCM treatment  experimental study

摘要:

[目的]观察扶肾降浊法对慢性肾功能衰竭大鼠的治疗作用。[方法]采用5/6肾切除所致的慢性肾功能衰竭动物模型,对大鼠的尿蛋白变化、血清肌酐、尿素氮、血浆心钠素(ANP)、醛固酮(ALD)、血清胆固醇、甘油三酯、血清白蛋白、总蛋白、钙磷代谢情况、血红蛋白、血清T₃、T₄、血压等进行了观察。[结果]扶肾降浊法能明显降低尿蛋白定量(P<0.01),降低肌酐、尿素氮水平(P<0.01),改善肾功能,降低血浆ANP、ALD水平,降低血脂(P<0.01),改善CRF大鼠低蛋白血症(P<0.01),调节钙磷代谢失调(P<0.01),纠正CRF大鼠贫血状况(P<0.05),降低血清T₃、T₄水平(P<0.01),降低血压(P<0.01)。[结论]扶肾降浊法对慢性肾功能衰竭具有显著的临床疗效。

Abstract:

[Objective] To observe the therapeutic effect of Fushen Jiangzhuo supporting kidney to eliminate turbid fluid on chronic renal failure CRF in rats. [Methods] CRF was established in rats by resection of 5/6 kidney. The changes of urinary protein,serum creatinine SCr,blood urea nitrogen BUN,plasma arterial matriuretic polypeptide ANP,aldosterone ALDOST,serum total cholesterol,triglyceride,serum albumin,total protein,metabolism of calcium and phosphorus, hemoglobin serum T₃,T₄,blood pressure etc were observed. [Results] This therapy could obviously reduce the quantity of urinary protein P<0.01,decrease SCr and BUN level P<0.01,improve the renal function,decrease level of plasma ANP,ALD and blood lipid P<0.01,improve hypoproteinemia P<0.01,regulate imbalance of calcium and phosphorus metabolism P<0.01,correct anemia P<0.05,reduce serum T₃,T₄ level P<0.01 and reduce blood pressure P<0.01. [Conclusion] "Method of supporting kidney to eliminate turbid fluid" has marked therapeutic effect on chronic renal failure.