化浊解毒法对2型糖尿病葡萄糖毒性作用的临床观察

Clinical Investigation on Effect of “Eliminate Turbid Fluid and Remove Toxicity” on Glucose Toxic Effect in Diabetes Ⅱ

关键词:  2型糖尿病  葡萄糖毒性作用  胰岛素抵抗  化浊解毒

Key words:  diabetes mellitus Ⅱ  glucose toxic effect  insulin resistance  "Eliminate Turbid Fluid and Remove Toxic"

摘要:

[目的]探讨化浊解毒法对2型糖尿病(DM)胰岛β细胞和胰岛素抵抗的影响。[方法]对慢性高血糖的2型DM病人32例在控制血糖的基础上,进行化浊解毒法及相应中药治疗2个月,比较治疗前后胰岛素(INS)和胰岛素敏感性指数(IAI)的变化,并与单纯控制血糖的对照组比较。[结果]空腹血糖(FBG)、胰岛素(FINS),糖化血红蛋白(HbA1c)均有下降(P<0.05),胰岛素敏感指数(IAI)较治疗前改善(P<0.01),明显优于对照组。[结论]葡萄糖毒性作用加重2型DM胰岛β细胞分泌缺陷和胰岛素抵抗,经化浊解毒法治疗后有利于胰岛β细胞恢复分泌功能和改善胰岛素抵抗从而减轻糖毒性。

Abstract:

[Objective] To explore the influence of "Eliminate Turbid Fluid and Remove Toxicicity" Method on islet β cells and insulin resistance. [Methods] On the basis of controlled blood sugar 30 cases of Diabetes Ⅱ with chronic hyperglycemia were treated with "Eliminate Turbid Fluid and Remove Toxic" Method and corresponding herbs for two months. The changes of insulin Ins and insulin sensitivity index ISI were compared before and after treatment and compared with that of patients with controlled blood sugar group alone. [Results] Fasting blood glucose FBG,fasting insulin FIns,glycosylated hemoglobin HBA were all decreased P<0.05,ISI was improved compared with that before treatment P<0.01,and the effect was obviously superior to the control group. [Conclusion] Glucose toxic effect will aggravate the secretion defect of islet β cells and insulin resistance in Diabetes Ⅱ,"Eliminate Turbid Fluid and Remove Toxic"method will be helpful to recover the secretion function of isletβcells and improve insulin resistance.