| 摘要: |
| [目的]探讨三七总皂苷(Panax Notoginseny Saponins,PNS)对大鼠急性心肌缺血(acute myocardial ischemia,AMI)模型血流动力学的影响。[方法]Wistar大鼠建立急性心肌缺血模型,随机分为假手术组、模型组、PNS小剂量组、PNS大剂量组。治疗7d后,分别测定左室血流动力学指标,包括左室收缩压(LVSP),左室舒张末期压(LVEDP),左室内压最大上升及下降速率(±dp/dtmax)。[结果]PNS可以降低LVEDP,升高±dp/dtmax。[结论]PNS治疗AMI可以改善心脏功能,大剂量应用对左室收缩和舒张功能均有显著提高作用。 |
| 关键词: 三七总皂苷 急性心肌缺血 血流动力学 |
| DOI：10.11656/j.issn.1672-1519.2005.02.33 |
| 分类号: |
| 基金项目:国家重点基础研究发展规划“973”资助项目(1999054403) |
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| Experimental Study on Effects of Panax Notoginseny Saponins on Hemodynamics in Rats with Myocardial Ischemia |
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LIU Jie, GAO Xiu-mei, WANG Yi
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Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To explore the effect of Panax Notoginseny Saponins (PNS) on the hemodynamics in rats with acute myocardial ischemia (AMI). [Methods] (AMI) was established in rats by ligature of coronary artery. They were randomly divided into sham-operated group,model group,small-dose group of PNS and large-dose group of PNS. After treatment for 7 days,the hemodynamic indexes of left ventricle (LVSP,LVEDP,±dp/dt max) were measured. [Results] PNS could reduce the LVEDP and increase the ±dp/dt max. [Conclusion] PNS can improve the cardiac function,and large-doses of PNS have marked improveing effect on systolic and diastolic function of left ventricle. |
| Key words: Panax Notoginseny Saponins acute myocardial ischemia (AMI) hemodynamics |
