荷叶总生物碱及其盐的提取和降脂作用的比较

Extraction of Folium Nelumbinis Total Alkaloid and Its Salt and Comparison in Lowering Blood Lipid between them

关键词:  荷叶总生物碱  提取  降脂

Key words:  Folium Nelumbinis total alkaloid  extraction  lowering blood lipid

摘要:

[目的]比较荷叶总生物碱及其盐的降脂作用。[方法]利用醇提取生物碱,酸水提取荷叶生物碱盐,再经大孔吸附树脂(药材与树脂的比例1:2)纯化,用乙醇-水洗脱,再分别对2型糖尿病(NIDDM)大鼠模型进行降血脂实验,以血清甘油三酯和胆固醇为指标,比较其降血脂作用的差异,采用SPSS8.0统计分析软件处理。[结果]荷叶生物碱盐组的降血脂作用明显优于碱组。[结论]荷叶生物碱盐组的降血脂作用强于生物碱。

Abstract:

[Objective] To compare the effect of Folium Nelumbinis total alkaloid and its salt on lowering blood lipid. [Methods] The alkaloid was extracted with alcohols,alkaloid salt was extracted with acid liquid purified by absorptive resin (medicinal materials:resin=1:2) and eluted with ethanol and water. After that the experiment of their lowering blood lipid was done in NIDDM rats respectively. Serum glycerin lipid and cholesterol are selected as the index,the difference between their effect on lowering blood lipid was compared and dealt with SPSS 8.0. [Results] The effect of alkaloid salt on lowering blood lipid was superior obviously to that of alkaloid. [Conclusion] Alkaloid salt possesses better effect on lowering blood lipid than alkaloid.