脂肪肝、高脂血症、糖尿病复合动物新模型的建立

Establishment of a Complex Animal Model for Fatty Liver,Hyperlipidemia and Diabetes

关键词:  家鸭  脂肪肝  高脂血症  糖尿病  动物模型

Key words:  duck  fatty liver  hyperlipidemia  diabetes  animal model

摘要:

[目的]探索建立脂肪肝、高脂血症、糖尿病复合模型。[方法]采用北京鸭,随机分为对照组和模型组。模型组填饲高糖饲料(玉米96.7%、调和油1.9%、食盐1.4%、禽用维生素10g/100kg),100g/(kg·d),观察体质量、血清脂质、血糖、肝脏脂质、肝脏病理形态学等指标。[结果]模型组家鸭体质量、肝指数、血清胆固醇(TC)、甘油三酯(TG)、血糖、肝组织TG均高于空白组,存在大量肝细胞脂肪变性。[结论]家鸭高糖饮食3周可复制脂肪肝、高脂血症、糖尿病复合模型。

Abstract:

[Objective]To investigate the method to establish a complex animal model for fatty liver,hyperlipidemia and diabetes.[Methods]Pekins were randomized into control group and model group.The Pekins of model group were fed with high glucose diet which consists of 96.7% corn,tempered edible oil 1.9%,salt 1.4%,avian vitamin 10 g/100 kg.The index of body weight,ratio of liver weight/body weight,blood sugar,serum grease,liver grease,liver pathology was observed.[Results] The body weight,ratio of liver weight/body weight,blood sugar,serum cholesterol,serum triglyceride and liver triglyceride of the model group were higher than that of the control group.Pathology of hepatocyte steatosis in liver was observed in the model group.[Conclusion] A complex animal model for fatty liver?hyperlipidemia and diabetes is successfully established in Pekins by 3 weeks high glucose diet.