针刺对急性心肌梗死模型犬在体心外膜单项动作电位的影响

Influence of Acupuncture on Epicardial Monophasic Action Potential in vivo in Dog with Myocardial Infarction

关键词:  针刺  急性心肌梗死模型犬  在体心外膜单项动作电位

Key words:  acupuncture  acute myocardial infarction  dog  epicardial monophasic action potential

摘要:

[目的]在临床针刺治疗急性心肌梗死合并心律失常获得满意疗效的基础上,探讨针刺治疗心律失常的机制。[方法]将实验动物随机分为针刺组、对照组,结扎动物冠状动脉前降支造模。[结果]针刺内关、三阴交,神门穴后,使造模动物缺血心肌细胞区域的单项动作电位电压(MAPA)与对照组相比较有所增高,上升速率也有所增加,单项动作电位时间(MAPD)各时限向正常的心外膜单相动作电位(MAP)方面发展,MAP的二位相平台和三位相斜率有所恢复。[结论]由此提示针刺可以改善MAP的去极化与复极化的整个过程,使缺血、缺氧的心肌得到不同程度的缓解,这可能是通过针刺增加冠状动脉血流量,心肌细胞间的联系加强,阻抗减小,快通道的反应性增强,促进了心肌细胞膜的稳定性。

Abstract:

[Objective] To explore the treatment mechanism of acupuncture on cardiac arrhythmia in animals on the basis of satisfied curative effect by acupuncture in treating cardiac infarction complicated with cardiac arrhythmia clinically.[Method] The experimental animals were divided randomly into acupuncture group and control group. Acute myocardial infarction was induced by ligation of anterior descending coronary artery.[Results] The monophasic action potential amplitude (MAPA) in the region of ischemic cardiac cells in infarcted animals in the acupuncture group increased much more than that in control group after giving acupuncture of NEI GUAN (P6),SAN YIN JIAO(SP6) and SHEN MEN(H7). The monophasic action potential duration (MAPD) in each time interval developed into the almost normal monophasic action potential of epicardium. The second phase platform and the third phase slope rate recovered at some extent.[Conclusion] The acupuncture may improve the whole course of monophasic action potential of depolarization and repolarization and relieve ischemia and anoxemia of cardiac muscle at different extent. The mechanism of acupuncture maybe related with the increasing volume of blood flow of coronary artery and the association of cardiac muscle cell,reducing the resisting power,enhancing the responsiveness of fast pathway and improving the stability of cardiac cytomembrane