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| 当归芍药散防治高脂血症的实验研究 |
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陈静1, 叶平1, 阎艳丽2, 宋晓雨2, 李清2, 李春花2, 王鑫国2
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1.中国人民解放军总医院, 北京, 100853;2.河北医科大学中医学院, 石家庄, 050091
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| 摘要: |
| [目的]观察当归芍药散对高脂血症的防治作用并初步探讨其作用机制。[方法]采用饲养法建立家兔高脂血症模型,观察当归芍药散对高脂家兔的血清脂质、肝脏脂质的影响。[结果]当归芍药散可以显著降低高脂血症模型家兔血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、载脂蛋白B100(ApoB100)水平,升高高密度脂蛋白(HDL-C)和载脂蛋白AI(ApoAI)水平,降低肝组织TC、TG,抑制脂质在肝脏的沉积。[结论]当归芍药散防治高脂血症的作用机制可能与以上因素密切相关。 |
| 关键词: 当归芍药散 高脂血症 家兔 血脂 肝脂质 |
| DOI：10.11656/j.issn.1672-1519.2005.06.27 |
| 分类号: |
| 基金项目:河北省教育厅科研计划内课题(2003261) |
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| Preventing and Treating Effect of Danggui Shaoyao Powder on Hyperlipemia in Rabbits |
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CHEN Jing,YE Ping,YAN Yan-li
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The General Hospital of Chinese People’s Liberation Army, Beijing 100853, China
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| Abstract: |
| [Objective] To observe the effect of Danggui Shaoyao powder(Angelica sinensis and Radix paeoniae powder) in preventing and treating hyperlipemia in rabbits and the primary mechanism.[Methods] The hyperlipemia in rabbit was induced by the breeding method. The influence of Danggui Shaoyao powder on the serum and liver lipid in hyperlipemia rabbit was observed.[Results] the Danggui Shaoyao powder could obviously decrease the serum TC,TG,LDL-C,AppoB100 level,increase the HDL-C and ApoA1,decrease the TC and TG of liver tissue and inhibit the liver lipid deposit in hyperlipemia rabbit.[Conclusion] The mechanism of Danggui Shaoyao powder in preventing and treating hyperlipemia maybe closely correlated with above factors. |
| Key words: Danggui Shaoyao powder hyperlipemia rabbit blood-fat liver lipid |
