| 摘要: |
| [目的]研究救心胶囊对缺氧和低密度脂蛋白(LDL)血管内皮细胞(EC)损伤的保护作用。[方法]采用体外细胞培养技术,制造缺氧和LDL内皮损伤模型。采用免疫组化方法观察救心胶囊对血管内皮黏附分子-1(VCAM-1)和细胞间黏附分子-1(ICAM-1)的影响。[结果]在缺氧或者LDL状态下,内皮细胞黏附分子(VCAM-1,ICAM-1)表达显著增加。救心胶囊可明显地抑制内皮细胞黏附因子的表达率。[结论]救心胶囊对缺氧和LDL造成的内皮细胞有保护作用。 |
| 关键词: 救心胶囊 内皮细胞 内皮黏附分子-1 细胞间黏附分子-1 |
| DOI：10.11656/j.issn.1672-1519.2005.06.31 |
| 分类号: |
| 基金项目:天津市卫生局资助课题(02042) |
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| Influence of Jiuxin Capsule on Expression of Adhesion Factors in Damaged Endothelial Cells |
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JIN Hui-min,LI Pei-fen,LIU Liang
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Tianjin University of TCM, Tianjin 300193, China
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| Abstract: |
| [Objective] To study the proective effect of Jiuxin capsule against hypoxia and blood endothelium injury by low density lipoprotein(LDL).[Methods] Hypoxia and blood endothelium injury were induced in cell culture in vitro. The influence of Jiuxin capsule on adhesion molecule-1(VCAM-1) and intercellular adhesion molecule-1(ICAM-1) in blood endothelium was observed with immunohistochemistry.[Results] The expression of VCAM-1 and ICAM-1 was obviously increased in the hypoxia or LDL state. The Jiuxin capsule may obviously down-regulated this expression.[Conclusion] The Jiuxin capsule may protect the endothelium cell against injury induced by hypoxia and LDL. |
| Key words: Jiuxin capsule endothelium cell VCAM-1 ICAM-1 |
