益气活血化痰法治疗不稳定性心绞痛临床研究

Clinical study on unstable angina with Yiqihuoxuehuatan method in 60 patients

关键词:  不稳定性心绞痛  益气活血化瘀法  血浆内皮素-1  C反应蛋白

Key words:  unstable angina  the method of promoting circulation of qi and blood and dispersing phlegm  ET-1  CRP

摘要:

[目的]观察益气活血化痰法治疗不稳定性心绞痛的疗效并探讨作用机制。[方法]将不稳定性心绞痛患者60例随机分为对照组和治疗组,服药4周,观察典型心绞痛发作频率、心电图缺血型ST段压低幅度和血浆内皮素-1(ET-1)、C反应蛋白(CRP)浓度变化。[结果]与对照组比较,治疗组心绞痛发作频率显著减少、心电图结果改善和血浆ET-1、CRP浓度显著降低(P<0.05);与治疗前比较,治疗组治疗后不稳定性心绞痛患者的心绞痛发作频率和血浆ET-1、CRP浓度亦显著下降(P<0.05),心电图结果显著改善(P<0.05);对照组治疗后心绞痛发作频率减少(P<0.05)、心电图结果和血浆ET-1、CRP浓度无显著下降(P>0.05)。[结论]益气活血化痰法治疗不稳定性心绞痛效果明显,并对血浆ET-1、CRP有显著降低作用

Abstract:

[Objective] To observe the clinical effect of Yiqihuoxuehuatan (promoting circulation of qi and blood and dispersing phlegm) method in treating patients with unstable angina (UA) and discuss the effect mechanism. [Methods] The prospective,randomized controlled study was conducted in 60 selected patients with UA. They were randomly assigned to the treated group and controlled group. The course of treatment was four weeks. The frequency of angina pectoris,the amplitude of ischemic depressed ST segment of EKG and the changes of the concentration of ET-1 and CRP were observed. [Results] After treatment,the frequency of angina pectoris and the result of EKG and the concentration of ET-1 and CRP in the treated group were improved significantly when compared with that in the control group (P<0.05). The frequency of angina pectoris after treatment in both groups were reduced significantly (P<0.05). The result of EKG and the concentration of ET-1 and CRP in the treated group after treatment were improved significantly while that in the control groups was not improved obviously (P>0.05). [Conclusions] The method of promoting circulation of qi and blood and dispersing phlegm can obviously improve the clinical condition of patients with UA and reduce the concentration of ET-1 and CRP.