| 摘要: |
| [目的]探讨黄芩苷的神经保护作用与促进内源性神经前体细胞(NPC)的关系。[方法]以Wistar大鼠双侧大脑皮质为标本,培养星形胶质细胞,采用聚合酶链式反应(PCR)方法检测趋化因子mRNA的表达。[结果]黄芩苷处理的缺氧星形胶质细胞能促进NPC的迁移。[结论]黄芩苷对神经有保护作用,为临床应用提供了实验依据。 |
| 关键词: 神经前体细胞 迁移 星形胶质细胞 缺氧 黄芩苷 血管内皮生长因子 单核细胞趋化蛋白-1 |
| DOI：10.11656/j.issn.1672-1519.2007.05.38 |
| 分类号: |
| 基金项目:日本文部省高科技研究中心基金资助项目。 |
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| Effect of baicalin on migration of nerves precursor cell by interfering with hypoxia in astrocyte |
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Yisidatoulawo1, XU Qiang2, JIANG Xi-juan2
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1.Japan;2.Tianjin University of TCM, Tianjin 300193, China
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| Abstract: |
| [Objective] To explore the relation between the neuroprotective effect of baicalin and endogenous nerves precursor cell(NPC). [Methods] Taking the two-side cerebral cortex in Wistar rats as the sample to cultivate astrocyte and determine the mRNA expression of chemotatic factor with PCR.[Results] The hypoxia astrocyte treated with baicalin may promote the migration of NPC.[Conclusions] The baicalin has a certain neuroprotective effect and has provided some experimental basis for its clinical application. |
| Key words: nerves precursor cell migration astrocyte hypoxia baicalin VEGF MCP-1 |
