针灸对去势大鼠骨代谢影响的生化研究

Biochemical research on effect of acupuncture and moxibustion on bone metabolism in castrated rats

关键词:  针灸  骨质疏松  碱性磷酸酶  脱氧吡啶啉

Key words:  acupuncture and moxibustion  ALP  DPD

摘要:

[目的]探讨针灸对骨质疏松症的治疗机制。[方法]将40只大鼠随机分为4组,即假手术组、模型组、针刺组及艾灸组。造模后,针刺组及艾灸组每天分别针刺和艾灸肾俞、三阴交,以上各组处理60d,第61天取血及尿,检测碱性磷酸酶(ALP)、脱氧吡啶啉(DPD)。[结果]针刺组和艾灸组血中ALP相对于模型组均明显提高,同时针刺组和艾灸组尿中DPD明显低于模型组。[结论]针灸对去势后大鼠的骨代谢有良性调整作用。

Abstract:

[Objective] To observe the bone metabolism-related biochemical changes in urine in castrated rats and explore the therapeutic mechanism of acupuncture and moxibustion in treating osteoporosis. [Methods] Forty Wistar rats were divided into 5 groups:sham operation group, model group, acupuncture group and moxibustion group. After the model was established, the rats in acupuncture and moxibustion were given acupuncture and moxibustion at the point of "shenshu", "sanyinjiao" once a day for altogether 60 days. After that in the next day, blood and urine were obtained for determination of ALP and DPD. [Results] In both treatment groups blood ALP was increased when compared with that of model group. Simultaneously, their DPD concentration in urine was significantly lower than that in control group. [Conclusions] Acupuncture and moxibustion possesses a benign regulatory effect on bone metabolism in castrated rats.