| 摘要: |
| [目的]从糖尿病多因素致病角度出发,探讨情志因素对糖尿病发病的作用机制——气机失调证,以及具有理气降逆散结功效的复方中药心身5号方的调节作用。[方法]采用旋转、拥挤、限制3种情志刺激结合腹腔注射少量链脲佐菌素(STZ)的实验方法,制作了糖尿病大鼠模型,实验动物分为正常组、应激组、STZ组、应激+STZ组和中药组。检测血清胰高血糖素和肝脏环磷酸腺苷(cAMP)含量,同时观察具有理气降逆散结功效的复方中药心身5号方的调节作用。[结果]慢性情志应激可促使STZ鼠血清胰高血糖素含量,肝脏中cAMP含量明显升高,与其他组比较有极显著性差异(P<0.01),中药可降低血清胰高血糖素和肝脏中cAMP含量。[结论]慢性情志刺激引起实验性糖尿病大鼠血清胰高血糖素和肝脏cAMP含量的升高是糖尿病发病机制之一,同时具有理气降逆散结功效的复方中药心身5号方有明显调节作用。 |
| 关键词: 情志刺激 胰高血糖素 环磷酸腺苷 |
| DOI：10.11656/j.issn.1672-1519.2008.02.25 |
| 分类号: |
| 基金项目:天津市卫生局中医中西医结合科研项目资助(200017) |
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| Influence of emotional stimulation on serum glucagon and so on in rats with diabetes mellitus |
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LIU Yan-min1, LI Jie2, TAN Zhan-shan1
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1.The Emergency Department of PLA 272 Hospital, Tianjin 300020, China;2.The psychological Department of Neimenggu Normal University, Huhehaote 010000, China;3.Tianjin University of TCM, Tianjin 300193, China
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| Abstract: |
| [Objective] To explore the effect mechanisms of emotion stimulation on DM onset(Qi-ji disorder syndrome),and the regulatory action of Xinshen NO.5,a compound prescription having effect of regulating Qi,lowering the abnormal ascending Qi and dispersing accumulation of pathogen from the pathogenesis with many factors.[Methods] The DM disease was induced by abdominal injecting a small dosage of STZ combined with psychophysiological stimulation(rotation,restraint and crowding) simultaneously.The animals were divided into five groups: normal group,stress group,STZ group,stress+STZ group and treatment group by Chinese herbs.Each group was checked the level of serum glucagons and cAMP.At the same time we observed the regulatory action of compound formula Xinshen NO.5.[Results] Emotional stimulation could make the STZ rats’ serum glucagon level and the cAMP level of liver increased.The STZ plus stimulation group had the highest level(P<0.01,or P<0.05).Chinese herb could lower the level.[Conclusions] The serum glucagon and cAMP level increased by chronic emotional stimulation was one of the caused mechanisms for DM onset.The regulatory action of compound formula Xinshen NO.5.is apparent. |
| Key words: emotion stimulation serum glucagons cAMP |
