清热降浊活血化瘀法治疗慢性肾小球肾炎60例临床观察

Clinical observations on qingrejiangzhuohuoxue decoction in treating chronic glomerular nephritis in 60 Cases

关键词:  慢性病  肾小球肾炎  中药疗法

Key words:  chronic disease  glomerular nephritis  pharmacotherapy

摘要:

[目的]观察清热降浊活血化瘀法加减治疗慢性肾小球肾炎的临床疗效。[方法]治疗组60例,予医肾汤治疗,药物组成:白茅根、茯苓、玄参、金银花、炒栀子、蒲黄、益母草、泽泻、生甘草。对照组60例,药用主要口服苯那普利控制蛋白尿及利尿、降低、抗凝等综合治疗。主要观察两组的血压及24h尿蛋白定量治疗前后的变化。[结果]治疗组:痊愈21例,显效33例,有效4例,无效2例。对照组:痊愈9例,显效18例,有效12例,无效21例。治疗前两组间血压和24h尿蛋白定量数据无显著性差异(P>0.05),治疗后两组24h尿质白变化均有较明显差异(P<0.01,P<0.05);治疗后血压治疗组效果较好(P<0.05),对照组治疗前后血压效果不明显(P>0.05),部分患者的肾功能均有显著改善(P<0.01,P<0.05)。[结论]中药医肾汤加减治疗慢性肾小球肾炎较单纯应用西药治疗慢性肾小球肾炎的疗效显著(P<0.01或P<0.05)。

Abstract:

[Objective] To observe the clinical effect of Qingrejiangzhuohuoxue decoction in treating chronic glomerular nephritis. [Methods] The patients of treatment group were administrated with Yishen decoction composed of lalang grass rhizome, smilacis glabrae, the chinaroot, the dried rehmannia, the scrophularia, the honey suckle, fries the gardenia, the cattail pollen, the leonurus siribicus, the oriental water plantain, the licorice, etc. The patients of control group were given combined therapy including oral administration of benzene that could control the albuminuria and the diuresis, voltage dropping resistor, the antifreeze, and so on. The main observation parameters were blood pressure, and 24 hour urine protein change of two groups. [Results] Twenty-one patients were fully recovered from the illness, thirty-three patients got excellence action, four patients were effective, two patients were ineffective in the treatment group. Nine patients were fully recovered from the illness, eighteen patients had excellence result, twelve patients were effective, twenty-one patients were ineffective in the control group. The blood pressure and 24 hour urine protein of treatment group were obviously differentiated from that of control group(P<0.01, P<0.05). The kidney function of some patients was obviously improved in treatment group (P<0.05, P<0.01). [Conclusions] The curative effect of Yishen decoction was obviously higher than that of Western medicine group in treating chronic glomerular nephritis(P<0.05, P<0.01).