温肺定喘膏辅助治疗儿童支气管哮喘寒饮停肺证96例临床研究

Treating childhood bronchial asthma with syndrome of cold fluid-retention suspend in lung with Wenfei Dingchuan ointment in 96 cases

关键词:  温肺定喘膏  儿童支气管哮喘  寒饮停肺证  临床研究

Key words:  Wenfei Dingchuan ointment  childhood bronchial asthma  syndrome of cold fluid-retention suspend in lung  clinical research

摘要:

[目的]评价温肺定喘膏辅助治疗儿童支气管哮喘寒饮停肺证的有效性和安全性。[方法]将96例患者按随机、安慰剂平行对照、双盲加载试验的方法分为试验组和对照组,在氨茶碱基础治疗的基础上,分别给予温肺定喘膏和安慰剂,治疗前后记录临床症状、体征、最大呼气流速(PEFR)、嗜酸粒细胞等情况。[结果]试验组疾病疗效与中医证候疗效均优于对照组,且试验组对证候计分和、主症计分和以及喘息、哮鸣、恶寒怕冷单项症状均有明显改善作用,与对照组比较有显著性差异。试验组1例药物周围黏膜处皮肤红痒,考虑系黏膜基质过敏所致,实验室检查未发现有临床意义的改变。[结论]温肺定喘膏对儿童支气管哮喘寒饮停肺证具有辅助治疗作用,安全性好,具有临床使用价值。

Abstract:

[Objective] To evaluate the effect and safety of Wenfei Dingchuan ointment (warming the lung and ameliorating asthma, WFDC) in treating childhood bronchial asthma with syndrome of cold fluid-retention suspend in lung.[Methods] According to a randomized, placebo-controlled 3:1 and double-blind loading test method, 96 patients were randomly divided into treatment group and control group. The patients of both groups were treated with aminophylline. On this basis, WFDC and placebo were given respectively. The symptoms, signs, PEFR, eosinophils, and so on were recorded before and after treatment.[Results] The clinical effect of treatment group was obviously higher than that of control group, and WFDC could obviously improve the syndrome and the individual symptoms of breathing, Wheezing, and Wuhanpaleng (aversion to cold). The rates of adverse reaction two groups were 1.39% and 9.09% respectively.[Conclusion] WFDC has a good adjuvant therapy effect in treating bronchial asthma with syndrome of cold fluid-retention suspend in lung, the incidence of adverse reactions was low, security was better, having a better clinical application value.