益气活血解毒法对溃疡性结肠炎复发患者结肠组织P-糖蛋白的影响

Influence of supplementing Qi,activating blood flow and detoxicating on P-glucoprotein in colon tissue in patients with recurrent ulcerative colitis

关键词:  结肠炎,溃疡性  抗复发  益气活血解毒  P-糖蛋白

Key words:  ulcerative colitis  anti-recurrence  supplementing Qi  activating blood flow and detoxicating  P-glucoprotein

摘要:

[目的]探讨益气活血解毒法对溃疡性结肠炎(UC)复发患者结肠组织P-糖蛋白影响。[方法]90例UC复发患者随机分为2组,中药治疗组45例,西药对照组45例。治疗3个月后对完全缓解及有效病例(其中治疗组39例,对照组32例)进行为期6个月的随访。治疗组给予益气活血解毒立法的中药汤剂,对照组给予柳氮磺胺吡啶治疗,并与20例作正常对照。[结果]治疗前UC组结肠组织P-糖蛋白水平明显高于正常健康人(P<0.01);复发组水平明显高于未复发组(P<0.01);治疗组治疗后及随访时结肠组织P-糖蛋白水平明显低于对照组(P<0.01)。[结论]以益气活血解毒立法的中药溃结复发方,与西药柳氮磺胺吡啶比较,可有效降低结肠组织P-糖蛋白水平,减少耐药性,提高药物的治疗效果从而降低复发率。

Abstract:

[Objective] To investigate the influence of supplementing Qi, activating blood flow and detoxicating treating on P-glucoproteinexpression in colon tissue of patients with recurrent ulcerative colitis (UC).[Methods] Ninety cases with recurrent UC were randomlydivided into treatment group (n=45) and control group (n=45) according to the random table.After treatment for three months, the cases ofcomplete remission and of with effective treatment were followed-up for 6 months. (treatment group, n=39;control group, n=32).Thepatients of treatment group accepted decoction of supplementing Qi, activating blood flow and detoxicating treatment while the controlgroup used Salazosulfapyridine.[Results] There were obvious differences between treatment group and control group.Before treatment,the level of colon tissue P-glucoprotein in UC group was much higher than that in health persons (P<0.01);the level of P-glucoprotein inrecurrent group was higher than that in non-recurrent group (P<0.01);but after treatment and follow-up period, the level of colon tissueP-glucoprotein in treatment group was lower than that in control group (P<0.01).[Conclusion] The study shows that decoction ofsupplementing Qi, activating blood flow and detoxicating treatment for patients with recurrent UC can more effectively decrease the levelof colon tissue P-glucoprotein than treatment with Salazosulfapyridine.At the same time, the drug-resistance is restrained, and this canraise the curative effect and decrease the recurrence of the disease.