疏肝导浊方对脂肪肝家兔的AST、ALT、ALP、NO、SOD和MDA的影响

The effect of Shugandaozhuo medicine on AST,ALT,ALP,NO,SOD and MDA in rabbit with fatty liver

关键词:  脂肪肝  疏肝导浊方药  超氧化物歧化酶  丙二醛  一氧化氮

Key words:  fatty liver  Shugandaozhuo Medicine  SOD  AST  ALT  ALP  NO  MDA

摘要:

[目的]观察疏肝导浊方对脂肪肝家兔肝功能及抗氧化作用的影响。[方法]采用高脂饲料喂饲家兔6周,诱导形成脂肪肝模型,实验分组为疏肝导浊方高、中、低(8、4、2g/kg)剂量组、东宝肝泰对照组、模型组和空白对照组,检测各组肝功能、超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)水平。[结果]模型组肝功能、SOD明显下降(P<0.05),MDA明显增加(P<0.01);疏肝导浊方中、低剂量组SOD明显升高(P<0.05)。[结论]疏肝导浊方可有效提高脂肪肝家兔的抗氧化作用。

Abstract:

[Objective] To observe the effects of Shuogandaozhuo Medicine (dispersing stagnation of liver-Q and reducing the turbid pathogen,SM) on liver function and its anti-oxygenation in rabbits with fatty liver.[Methods] The fatty liver in rabbits was induced by feeding them with high caloric diet for six weeks.Sixty rabbits were randomly divided into six groups including the high-dose,middledose and low-dose SM groups,the Dongbaogantai group,the model group and the normal control group.The liver index (liver weight/body weight),the amount of AST,ALT,ALP,NO,SOD and MDA in the serum were investigated after medication.[Results] The liver function and the amount of SOD decreased significantly (P<0.05) in the model group with significant increasing of the MDA (P<0.01);Significant increase of SOD was found in the middle and low-dose of the SM group (P<0.05).[Conclusion] SM is effective for increasing anti-oxidation in rabbits with fatty liver.