| 摘要: |
| [目的]采用病证结合的造模方法建立慢性阻塞性肺疾病(以下简称慢阻肺)痰瘀阻肺证大鼠模型。[方法]利用强迫游泳、烟熏、低氧环境耗伤肺气,使其肺气虚,引起痰饮瘀血内停,建立慢阻肺痰瘀阻肺证大鼠模型。4周后测大鼠肺功能、肺动脉压、血流变及心肺病理学观察。[结果]模型大鼠的症状、肺功能、肺动脉压、血流变及心肺病理学观察符合慢阻肺痰瘀阻肺证的表现。[结论]实验采用复合因素造模方法复制的慢阻肺痰瘀阻肺证模型符合中医学和现代医学原理,具有时间短、易复制、可操作性强的特点,亦符合临床的实际情况。 |
| 关键词: 慢性阻塞性肺疾病 痰瘀阻肺证 大鼠模型 |
| DOI：10.11656/j.issn.1672-1519.2010.01.22 |
| 分类号: |
| 基金项目:国家重点基础研究发展计划(973计划)项目(2008CB517404);国家自然基金项目(30572387) |
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| Establishment of rat model of chronic obstructive pulmonary disease with stagnated phlegm obstructing lung |
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LI Ze-geng, WANG Chuan-bo, PENG Bo
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The First Affiliated Hospital of Anhui College of TCM, Hefei 230031, China
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| Abstract: |
| [Objective] To establish the rat model of chronic obstructive pulmonary disease (COPD) with stagnated phlegm obstructing lung by combining the disease and symptoms.[Methods] The COPD with stagnated phlegm obstructing lung was established in rats with compelled swimming,exploding in the circumstances of smoke and hypoxia for 4 weeks.The pulmonary function,pulmonary arterial pressure,blood rheology and the pathological changes of the rats’ lung and heart were observed.[Results] The symptoms,pulmonary function,pulmonary arterial pressure,blood rheology and the pathological changes in the lung and heart in the model rats were coincident with COPD with stagnated phlegm obstructing.[Conclusion] This study has established a model of COPD with stagnated phlegm obstructing lung based on the principles of Chinese and Western medicine.This method is feasible and easy to be duplicated in a short period of time and compatible in the clinical practice. |
| Key words: COPD stagnated phlegm obstructing lung the rat model |
