| 摘要: |
| [目的]观察活血化瘀膏对早中期膝关节骨性关节炎的一氧化氮(NO)和基质金属蛋白酶-13(MMP-13)含量的影响及临床疗效,并与扶他林乳胶剂组做对照。[方法]将60例患者分成治疗组和对照组,活血化瘀膏为治疗组,用扶他林乳胶剂作对照,治疗1周及2周后,分别观察患者的美国特种外科医院膝关节评分(HSS)总分、疼痛积分,并进行计分对比研究,同时测定治疗组治疗前后关节液中NO和MMP-13含量,评价其临床疗效进行疗效观察。[结果]通过统计学分析,治疗组治疗1周及治疗2周后与治疗前进行HSS量表中HSS总分、疼痛积分,P<0。05;治疗组按疗程治疗前后关节液中NO含量经配对T检验,P<0。05。[结论]活血化瘀膏对早中期膝关节骨性关节炎有较好的治疗作用。 |
| 关键词: 活血化瘀膏 膝关节骨性关节炎 一氧化氮 基质金属蛋白酶-13 |
| DOI：10.11656/j.issn.1672-1519.2010.03.09 |
| 分类号: |
| 基金项目:天津市卫生局科研专项资金项目(07062) |
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| Effect of Huoxue Huayu plaster on NO and MMP-13 in joint fluid of osseous arthritis of knee in the early and middle stage |
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WANG Ping1, GU EN-peng1, CAO HONG-yu2
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1.The First Affiliated Hospital of Tianjin University of TCM, Tianjin 300193, China;2.Graduated College of Tianjin University of TCM, Tianjin 300193, China
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| Abstract: |
| [Objective] To study the effect of Huoxue Huayu plaster on NO and MMP-13 level in osseous arthritis of knee in the early and middle stage and the clinical therapeutic action taking voltaren emulsion as control.[Methods] Sixty cases with early and middle stage of osseous arthritis of knee were randomly divided into two groups:treatment and control groups.they were treated by huoxuehuayu Plaster and Voltaren respectively.One or two weeks later the HSS score,pain score,content of NO and MMP-13 were observed [Results] There was a significant difference in the HSS Scale total score,pain points and NO content between treating for 1 and 2 weeks and the condition before treatment(P<0.05).[Conclusion] The Huoxue Huayu Plaster can improve knee function and enhance stability. |
| Key words: Huoxue Huayu Plaster osseous arthritis of knee NO MMP-13 |
