胰活散临床治疗2型糖尿病的量效关系评价

Comment on dose-effect relationship of Yi Huo Powder in clinical treating type 2 diabetes

关键词:  2型糖尿病  胰活散  量效关系

Key words:  type 2 diabetes  Yi Huo Powder  dose-effect relationship

摘要:

[目的]观察胰活散临床治疗2型糖尿病的量效关系。[方法]给予二甲双胍基础治疗的2型糖尿病患者联合胰活散原方或胰活散精方治疗各60例30 d,观察两方治疗前后空腹血糖(FPG)、餐后2 h血糖(2 hPG)、总胆固醇(TC)、甘油三酯(TG)、糖化血红蛋白(HbA1c)水平及体质量变化情况。[结果]经两方治疗后患者FPG、2hPG及TC、TG与治疗前相比均显著降低(P<0.01),组间治疗后以上指标及HbA1c水平差异显著(P<0.05);气阴两虚兼血瘀症状方面改善率为精方的85.7%对原方的78.6%;但2组间治疗后体质量无显著差异(P>0.05)。[结论]胰活散精方较原方在降糖,降脂,降HbA1c水平及症状改善方面均有显著优势。

Abstract:

[Objective] To research the dose-effect relationship of "Yi Huo Powder" in the clinical treatment of type 2 diabetes.[Methods] 60 cases were treated with "Yi Huo Powder" primary prescription for 30 days and 60 cases were treated with "Yi Huo Powder" fine prescription for 30 days.The levels of fasting plasma glucose(FPG),two-hour postprandial plasma glucose(2hPG),total cholesterol(TC),triglyceride(TG),glycosylated hemoglobin(HbA1c)and body weight were observed.[Results] The levels of FPG,2hPG,TC,TG were decreased after treatment with two prescriptions(P<0.01).The levels of above indexes and HbA1c have significant difference between two groups after treatment(P<0.05).The improvement rate of deficiency syndromes involving Qi,Yin and blood-stasis was 96.7% in primary prescription and 80.0% in fine prescription,but body weight was improved without statistical significe between two groups(P>0.05).[Conclusion] "Yi Huo Powder" fine prescription has manifested superiority compared with the primary prescription in reducing PG,TC,TG,HbA1c and in improving symptom.