灯盏花素、阿魏酸钠联合贝那普利治疗早期糖尿病肾病的疗效观察

Treating early diabetic nephropathy with Breviscapine,Sodium ferulate combined with Benazepril

关键词:  早期糖尿病肾病  灯盏花素  阿魏酸钠  贝那普利

Key words:  early diabetic nephropathy  breviscapine  sodium ferulate  benazepril

摘要:

[目的]观察灯盏花素、阿魏酸钠联合贝那普利对早期糖尿病肾病(DN)患者尿蛋白及肾功能的影响。[方法]将86例早期DN患者随机分为A、B两组,A组为对照组,单用贝那普利;B组为治疗组,灯盏花素、阿魏酸钠及贝那普利联合应用,疗程均为4周,观察治疗前后24 h尿蛋白定量、尿白蛋白排泄率(UAER)、血β2微球蛋白(β2-MG)、尿素氮(BUN)、血肌酐(SCr)、空腹血糖(FPG)及总胆固醇(TC)。[结果]A、B组治疗后24 h尿蛋白定量、UAER、血β2-MG均有下降,B组下降更明显,A、B两组间差异有统计学意义(P<0.01)。治疗组治疗后血肌酐(SCr)、总胆固醇(TC)下降,与治疗前比较差异有显著性(P<0.05)而对照组治疗后无明显改变,两组间比较差异有显著性(P<0.05)。[结论]灯盏花素、阿魏酸钠联合贝那普利治疗早期DN,可明显的减少DN患者尿蛋白,改善肾功能,对肾脏具有明显的保护作用,可延缓DN的发生和发展。

Abstract:

[Objective] To investigate the effect of Breviscapin,sodium ferulate combined with benazepril on urinary protein and renal function in patients with early diabetic nephropathy.[Methods] 86 patients with early diabetic nephropathy were randomly divided into two groups.The control group(A) was treated with benazepril alone;the treatment group(B) was treated with breviscapine,sodium ferulate in combination with benazepril and the therapeutic course of 4 weeks in both groups.Before and after treatment,24h urinary protein,urinary albumin excretion rate(UAER),blood β2-MG,urea nitrogen(BUN),serum creatinine(SCr),fasting blood glucose(FPG) and total cholesterol(TC) were monitored.[Results] After treatment,24h urinary protein,UAER,blood β2-MG of two groups declined compared with pre-therapy;group B was declined more obviously and the difference between two groups was statistically significant(P<0.01).After treatment,SCr,TC of treatment group decreased compared with that before treatment(P<0.05).In the control group no significant change was found and the difference between two groups was significant(P<0.05).[Conclusion] In patients with early diabetic nephropathy,breviscapine,sodium ferulate combined with benazepril can significantly reduce urinary protein and improve renal function.It has significant protective effects for kidney,can delay the development and progression of diabetic nephropathy.