四妙勇安汤对2型糖尿病大鼠血管内皮细胞功能的影响

Effect of Simao Yongan Decoction on vascular endothelial cells function in diabetic rats

关键词:  四妙勇安汤  糖尿病血管病变  内皮功能

Key words:  Simao yongan decoction  diabetic peripheral vascular disease  vascular endothelial cells function

摘要:

[目的]通过观察四妙勇安汤对糖尿病大鼠血管细胞内皮功能的影响。[方法]选取2型糖尿病(T2DM)大鼠36只,按血糖结合体质量分层随机分为3组:模型组、罗格列酮治疗组、四妙勇安汤治疗组,另取12只大鼠作为正常对照组,给药4周后检测血清血管细胞间黏附因子(sVCAM-1),血浆一氧化氮(NO)、内皮细胞素-1(ET-1)、肿瘤坏死因子(TNF-α)。[结果]T2DM模型大鼠血清sVCAM-1、血浆TNF-α含量较正常对照组明显升高;血浆ET-1较正常组上调,NO明显下调。四妙勇安汤及罗格列酮均能显著降低血清sVCAM-1、血浆TNF-α及ET-1的含量,显著提高血浆NO含量(P<0.01)。[结论]四妙勇安汤具有血管内皮保护作用,能够阻滞或延缓糖尿病动脉粥样硬化的发展,降低糖尿病大鼠血管并发症风险。

Abstract:

[Objective] To detect the effect of Simao yongan decoction on the function of vascular endothelial cells through.[Methods] Thirty-six males Wistar rats were randomly divided into two groups:normal control group(twelve) and diabetic group.According to blood-glucose and body weight,they were randomly divided into three groups:model group,diabetic group treated with rosiglitazone and diabetic group with Simao yongan decoction.Every rat was respectively measured about their serums sVCAM-1,plasma TNF-α,NO and ET-1.[Results] Compared with control groups,the content of serums sVCAM-1 and plasma TNF-α increased significantly and plasma ET-1 increased slightly,while NO decreased significantly in diabetic rats.As a result,Simao yongan decoction and Rosiglitazone can significantly decreased the content of serum sVCAM-1,plasma TNF-α and plasma ET-1,while increased the content of plasma NO significantly.[Conclusion] Simao yongan decoction can protect the function of vascular endothelial cells and suppress the initiation and progression of atherosclerosis in diabetic rats.