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| Labrasol对葛根素角膜透过性的研究 |
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舒乐新1, 赵启铎2, 刘志东1, 李琳1, 宋西卫1, 李楠1
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1.天津中医药大学现代中药发现与制剂技术教育部工程研究中心, 天津, 300193;2.天津中医药大学, 天津, 300193
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| 摘要: |
| [目的]研究Labrasol对葛根素角膜透过性的影响。[方法]采用体外扩散实验考察不同浓度的Labrasol对葛根素角膜透过性的影响。[结果]Labrasol质量浓度为0.5%、1%、1.5%、2%、3%时,葛根素的表观渗透系数分别是对照组的1.87倍、4.41倍、7.42倍、8.02倍和9.60倍,与对照组比都有显著性差异(P<0.01)。[结论]质量浓度为0.5%～3%的Labrasol均能显著性的增加葛根素的表观渗透系数,且对角膜无刺激性。 |
| 关键词: 辛酸癸酸聚乙二醇甘油酯 葛根素 角膜透过性 |
| DOI：10.11656/j.issn.1672-1519.2010.06.31 |
| 分类号: |
| 基金项目:国际科技合作项目(2007DFC31670) |
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| Investigation of Labrasol on the corneal permeability of puerarin in vitro |
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SHU Le-xin1, ZHAO Qi-duo2, LIU Zhi-dong1
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1.Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministryof Education, Tianjin 300193, China;2.Tianjin University of TCM, Institute of Pharmacy, Tianjin 300193, China
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| Abstract: |
| [Objective] To explore the use of Labrasol in an ocular drug delivery system.[Methods] The effects of Labrasol on the cornealpermeability of puerarin were investigated in vitro,using isolated rabbit corneas.[Results] The 0.5%,1%,1.5%,2%,3% Labrasol showedincrement as much as 1.87,4.41,7.42,8.02 and 9.60 times in the apparent permeability of puerarin,respectively compared with the onesin the control(P<0.01).[Conclustion] The 0.5%～3% Labrasol can enhance the corneal apparent permeability of puerarin significantlyand is not irritant to eye tissues. |
| Key words: Labrasol puerarin corneal permeability |
