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| 酸枣仁总黄酮抗抑郁作用的实验研究 |
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赵启铎1, 舒乐新1, 王颖1, 牟佳佳1, 宋志国2, 李金梅2
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1.天津中医药大学中药学院, 天津, 300193;2.吉林熬东集团大连药业股份有限公司, 大连, 116043
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| 摘要: |
| [目的]研究酸枣仁总黄酮对行为绝望小鼠抑郁模型的影响。[方法]采用小鼠强迫游泳实验和悬尾实验等抑郁模型,小鼠行为绝望的不动时间作为指标,考察酸枣仁总黄酮抗抑郁活性。[结果]酸枣仁总黄酮低、中、高剂量组均能减少小鼠强迫游泳和悬尾不动时间,与空白组比较差异有统计学意义(P<0.05);与阳性药组比较差异有统计学意义(P<0.05)。[结论]酸枣仁总黄酮具有显著的抗小鼠实验性抑郁作用。 |
| 关键词: 酸枣仁 总黄酮 抗抑郁 行为绝望 |
| DOI：10.11656/j.issn.1672-1519.2011.04.26 |
| 分类号: |
| 基金项目:天津市高等学校发展项目基金(20070305) |
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| Study on the antidepressant effect of total flavonoids from Semen Ziziphi Spinosae |
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ZHAO Qi-duo,SHU Le-xin,WANG Ying
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School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To observe the antidepressant effect of total flavonoids from Semen Ziziphi Spinosae in mice.[Methods] To investigate the antidepressant activity of total Flavonoids from Semen Ziziphi Spinosae by the forced swimming test and the tail suspension test,with behavioral despair mice in the immobility time as an indicator.[Results] Different dose groups of total flavonoids from Semen Ziziphi Spinosae could significantly reduce the immobility time of mice during the forced swimming test and the tail Suspension test,compared with that of the control group(P<0.05);compared with that of the positive group(P<0.05).[Conclusion] The total flavonoids from Semen Ziziphi Spinosae possess had significant antidepressant effects. |
| Key words: Semen Ziziphi Spinosae total flavonoids antidepressant effect behavioral despair |
