中西医结合基础研究思路与方法探讨

Train of thought and methods of basic research in integrated traditional Chinese medicine and Western medicine

关键词:  系统论  还原论  肾虚  肾精  干细胞

Key words:  system theory  restoration theory  kidney deficiency  kidneyessence  stem cells

摘要:

整体观、系统论是中医药的重要特点, 中医药理论中也充满许多具有原创性的思想。课题组先是以还原论为指导, 进行了肾阳虚证与下丘脑-垂体-肾上腺皮质轴的研究, 近来利用系统生物学的思想, 在肾虚证(以衰老为模型)研究领域也进行了一些尝试。肾精是中医学的核心概念之一, 根据对中医肾精概念的深入发掘, 提出肾精内涵的干细胞理论, 并初步论证了肾精与干细胞的关联以及补肾填精药物激活内源性干细胞的作用。

Abstract:

The conception of whole and theory of system are the important features of traditional Chinese medicine (TCM). Among them many original ideas are also contained. Under the guidelines of theory of restoration at first, a research on the kidneyYang deficiency syndrome and the hypothalamus-pituitary-adrenal axis has been performed. Recently, employing the methods of systemic biology some researches in the field of kidneydeficiency syndrome (taking aging rats as a model) have been tried. Kidney essence was the key concept in TCM. According to the results of deep exploration on the concept of kidney essence in TCM the theory of stem cells in the connotation of kidney essence is suggested. It is provided that the kidney essence and stem cells are correlated and the herbs with invigorating kidney and replenishing essence can activate the intrinsic stem cells.