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| 灵芪胶囊对H22荷瘤小鼠COX-2蛋白表达的影响 |
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刘晓冬1,2, 代贵江1,2, 刘波1,2, 苏云明1,2
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1.牡丹江医学院附属第二医院, 牡丹江 157010;2.黑龙江中医药大学, 哈尔滨 150040
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| 摘要: |
| [目的] 研究灵芪胶囊(LQC)的抗肿瘤作用的机制。[方法] 以免疫组化方法检测荷瘤小鼠血管生成因子环氧化酶-2(COX-2)、表达的变化, 研究LQC对肿瘤血管生成的抑制作用。[结果] LQC能够下调血管生长因子COX-2的表达而抑制肿瘤生长。[结论] LQC通过影响COX-2的表达, 抑制肿瘤新生血管生成, 发挥抗肿瘤作用。 |
| 关键词: 灵芪胶囊 抗肿瘤 H22细胞株 血管生成因子环氧化酶-2 |
| DOI：10.11656/j.issn.1672-1519.2013.02.13 |
| 分类号: |
| 基金项目:2005黑龙江中医药大学科研基金资助项目(200503). |
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| Effect of Lingqi capsule on the expression of COX-2 in H22 tumor-bearing mice |
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LIU Xiao-dong1,2, DAI Gui-jiang1,2, LIU Bo1,2, SU Yun-ming1,2
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1.The Second Affiliated Hospital of Mudanjiang Medical College, Mudanjiang 157010, China;2.Heilongjiang University of TCM, Ha'erbin 150040, China
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| Abstract: |
| [Objective] To study the anti-tumor effect of Lingqi capsules (LQC) and further explore the mechanism of action. [Methods] The expression of angiogenic factor COX-2 was detected in tumor-bearing mice with immunohistochemical methods and to the LQC's inhibitory action to tumor angiogenesis was detected also. [Results] LQC could inhibit the tumor angiogenesis by down-regulating the expression of angiogenic factor COX-2. [Conclusion] LQC shows its anti-tumor effect by influencing the expression of angiogenesis-correlated factor and inhibiting the tumor angiogenesis. |
| Key words: Lingqi capsule Anti-tumor H22 COX-2 |
