小半夏加茯苓汤治疗化疗致 迟发性呕吐的临床疗效观察

Clinical effect of Poria cocos plus Little Pinellia ternata decoction in treating chemotherapy induced delayed nausea and vomiting

关键词:  小半夏加茯苓汤  化疗  迟发性呕吐

Key words:  Poria cocos plus Little Pinellia ternata decoction  chemotherapy  delayed chemotherapy induced nausea and vomiting

摘要:

[目的] 评价小半夏加茯苓汤治疗化疗迟发性呕吐的有效性和安全性。[方法] 2011年3月-2012年5月对91例符合入选标准的患者进行随机分组、平行对照研究。治疗组(小半夏加茯苓汤治疗)46例, 对照组(甲氧氯普安治疗)45例, 连续用药3 d,比较两组疗效。严密观察和记录治疗过程中的不良事件, 进行安全性评价。[结果] 治疗组止呕有效率较对照组组间差异明显, P<0.05.两组均未出现不良事件, 安全性较好。[结论] 小半夏加茯苓汤治疗化疗迟发性呕吐有较好的疗效。

Abstract:

[Objective] To evaluate the efficacy and safety of Poria cocos plus Little Pinellia ternata decoction in the treatment of delayed chemotherapy induced nausea and vomiting. [Methods] From March, 2011 to May, 2012, 91 patients with delayed chemotherapy induced nausea and vomiting were randomized into two groups for parallel-controlled study. The treatment group (46 patients) was treated by Poria cocos plus Little Pinellia ternata decoction for 3 days, while the control group (45 patients) by metoclopramide. We compared the curative effect of two groups. The occurrences of adverse events were evaluated as well. [Results] There had obvious differences in curative effect between treatment group and control group. In both groups no adverse events were found. [Conclusion] Poria cocos plus Little Pinellia ternata decoction has good curative effect in the treatment of delayed chemotherapy induced nausea and vomiting.