纤花线纹香茶菜和溪黄草水提物的抗炎作用比较研究

Comparative study of anti-inflammatory effects between extracts of Isodonis Lophanthoidis var. graciliflora and Rabdosia serra

关键词:  纤花线纹香茶菜  溪黄草  抗炎

Key words:  Isodonis Lophanthoidis var. graciliflor  Rabdosia serra  anti-inflammatory

摘要:

[目的] 观察对比纤花线纹香茶菜和溪黄草属植物溪黄草水提物的抗炎作用.[方法] 取SPF级昆明种小鼠随机分为模型对照组、阳性药物组[阿司匹林(0.2g/kg)]、纤花线纹香茶菜水提物组(2.57、1.28、0.64g/kg)、溪黄草水提物组(2.67、1.33、0.67g/kg).每天1次,连续灌胃给药5d.末次给药后约1h选用二甲苯致耳肿胀、醋酸致腹腔炎症方法观察抗炎作用.[结果] 纤花线纹香茶菜水提物能明显降低二甲苯致耳肿胀度和抑制醋酸致腹腔毛细血管通透性增高,而溪黄草水提物未见明显影响二甲苯致小鼠耳肿胀度,在抑制醋酸致小鼠腹腔毛细血管通透性增高时,其抗炎活性也明显低于纤花线纹香茶菜水提物.[结论] 纤花线纹香茶菜水提物的抗炎作用强于溪黄草水提物.

Abstract:

[Objective] To study and compare the anti-inflammatory effects of extracts from Isodonis Lophanthoidis var.graciliflora and Rabdosia serra.[Methods] SPF Kunming mice were divided into model group,aspirin group(0.2 g/kg),Isodonis Lophanthoidis var.graciliflora water extract group (2.57,1.28,0.64 g/kg) group and Rabdosia serra extract (2.67,1.33,0.67 g/kg) groups.Each drug was administrated to mice orally once a day for 5 days.1 h after the last administration, the anti-inflammatory effects were observed by methods of xylene-induced auricular swelling and acetic acid-induced peritoneal inflammation, respectively.[Results] The water extract of Isodonis Lophanthoidis var.graciliflora could markedly decrease xylene-induced auricular swelling and inhibit acetic-acid induced increasing of permeability in peritoneal capillary in mice.But Rabdosia serra extract had no marked anti-inflammatory effects in decreasing the swelling of ear, and had less anti-inflammatory effects to decrease the increasing of the permeability of peritoneal capillary in less degree than Isodonis Lophanthoidis var.graciliflora extract.[Conclusion] The water extract of Isodonis Lophanthoidis var.graciliflora has stronger anti-inflammatory activities than Rabdosia serra extract does.