临床阳虚患者身体机能状态研究

Clinical study on functional state in patients with Yang deficiency

关键词:  阳虚患者  内分泌系统  免疫系统  物质能量代谢

Key words:  patients with Yang deficiency  endocrine system  immune system  substance and energy metabolism

摘要:

[目的] 对临床阳虚患者身体机能状态进行研究,以期为虚寒状态模型研究提供依据。[方法] 收集符合纳入标准,且不符合排除标准的阳虚患者和健康对照者。阳虚患者30例,均来自北京中医药大学第三附属医院和东直门医院住院及门诊患者,健康对照者30例来自北京中医药大学职工。阳虚病人和健康对照者均在清晨7点半至8点,抽取静脉血3 mL,分离血清。全自动生化分析仪检测血清免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、补体3(C3)、补体4(C4)、乳酸(LAC)、血糖(GLU)、总胆固醇(TC)、甘油三酯(TG)、总蛋白(TP)、白蛋白(ALB),放射免疫法检测血清皮质醇(COR)、三碘甲腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH).[结果] 与健康人比较,阳虚病人血清中IgM、LAC、T3、COR明显降低(P<0.05),GLU和TC的含量偏高(P<0.01,P<0.05),其他指标变化不明显。[结论] 临床阳虚患者在内分泌系统功能、物质能量代谢和免疫功能等方面表现出功能低下或紊乱。

Abstract:

[Objective] To investigate the physical functional state in patients with Yang deficiency. [Methods] Thirty patients with Yang deficiency from the third affiliated hospital of Beijing University of Chinese Medicine and Dongzhimen hospital were enrolled and thirty healthy controls were collected from Beijing University of Chinese Medicine. Between 7:30 a.m. to 8:00 a.m, about 3mL of blood samples were obtained from vein of each patients with deficiency and healthy control. Serum levels of IgG, IgM, C3, C4, LAC, GLU, TC, TG, TP and ALB were detected by automatic biochemical analyzer and serum levels of COR, T3, T4 and TSH were determined by radio-immunity methods. [Results] Compared with the healthy controls, the serum levels of IgG, LAC, T3 and COR of patients with Yang deficiency were significantly lower(P<0.05), while serum levels of GLU and TC were significantly higher(P<0.01, P<0.05). The other indexes had no obvious change. [Conclusion] During the trial process, the function of immune system, endocrine system and substance and energy metabolism are significantly lower or with disorder in patients with Yang deficiency.