冠心病痰瘀互结证动物模型的建立及机制探讨

The study on establishment and mechanism of animal model about coronary heart disease with phlegm and blood stasis syndrome

关键词:  中医证候  冠心病痰瘀互结证  动物模型  转基因动物

Key words:  traditional Chinese medicine syndrome  coronary heart disease with phlegm and blood stasis  animal model  transgenic animal

摘要:

中医证候动物模型是在中医整体观念及辨证论治思想的指导下把人类疾病的某些特征在动物上加以模拟，复制出与人体疾病症状和病理改变相同或相似的动物模型。冠心病痰瘀互结证动物模型的建立是研究疾病发生、发展及药物疗效评价必不可少的工具。目前，建立冠心病痰瘀互结证动物模型常用的方法有两类，一是病证结合与中西医结合模型，二是转基因动物模型。现仅就这两类动物模型进行探讨。

Abstract:

Animal models of traditional Chinese medicine syndrome is to analogue and replicate some features of the human disease, having the same symptom and pathology of human under the guidance of the overall concept of traditional Chinese medicine and syndrome differentiation. The animal models of coronary heart disease with syndrome of phlegm and blood stasis is the essential tool, which can study the development of disease and the evaluation of drug efficacy. At present, the common establishing methods of the animal models of coronary heart disease with syndrome of phlegm and blood stasis mainly include two kinds. The one is the combination of disease and syndrome as well as integrated traditional Chinese and Western medicine animal model, and the other one is transgenic animal model. Now this paper only investigated these two animal models.