| 摘要: |
| [目的] 探讨凉血消风汤加减治疗血热型银屑病的机制及对外周血白介素-愿（陨蕴原愿）水平的影响。[方法] 采用酶联免疫吸附试验（ELISA）法观察了40例血热型银屑病患者应用凉血消风汤治疗前后外周血IL-8水平的变化，同时观察了凉血消风汤的疗效。[结果] 血热型银屑病患者外周血IL-8水平明显高于对照组（P<0.01）；治疗8周后，血热型银屑病患者外周血IL-8明显降低，与治疗前比较差异有统计学意义（P<0.01），治疗后PASI（银屑病皮损面积和严重程度指数）评分较治疗前明显降低（P<0.01）。[结论] 凉血消风汤治疗血热型银屑病有效，可能通过降低IL-8的水平，抑制中性粒细胞及T淋巴细胞聚集，减轻局部炎症，从而减轻血热型银屑病的症状。 |
| 关键词: 凉血消风汤 血热型银屑病 白介素-8 |
| DOI：10.11656/j.issn.1672-1519.2014.04.07 |
| 分类号: |
| 基金项目:天津市卫生局中医处科研基金资助项目（13019）。 |
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| Therapeutic effect of modified Liangxue Xiaofeng decoction and effect on peripheral interleukin-8 in patients with psoriasis with blood heat syndrome |
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XIE Yan-qiu, KONG Xiang-jun, DAI Wei-wei, NIE Zhen-hua
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Department of Dermatology, The Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China
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| Abstract: |
| [Objective] To explore the therapeutic mechanism of modified Liangxue Xiaofeng decoction and the effect on interleukin-8(IL-8) of peripheral blood in patients with psoriasis with blood heat syndrome. [Methods] The level of IL-8 before and after treatment by modi-fied of Liangxue Xiaofeng decoction for 8 weeks was measured in patients by ELISA methods. [Results] IL-8 of peripheral blood were higher in patients than that in controls (P<0.01). After treatment, IL-8 of peripheral blood and the PASI were lower than that before (P<0.01). [Conclusion] The modified of Liangxue Xiaofeng decoction may reduce psoriatic symptoms by reducing the activation of com-plement and inhibiting the inflammation reaction. |
| Key words: Liangxue Xiaofeng decoction psoriasis with blood heat syndrome Interleukin-8 |
