血必净注射液对复苏后的多器官功能障碍患者脏器保护作用的研究

Protective effects of Xuebijing injection against organ injury in patients with MODS after cardiac pulmonary resuscitation

关键词:  CPR  MODS  血必净  细胞因子

Key words:  CPR  MODS  Xuebijing  cell factor

摘要:

[目的] 评价血必净注射液治疗复苏后多器官功能障碍的临床效果。[方法] 采用随机分组方法，将98 例确诊复苏后多器官功能障碍患者分为治疗组和对照组。观察治疗前后主要临床症状、体征变化、血清肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）以及多器官功能变化。[结果] 与对照组比较，血必净治疗后，血清TNF-α、IL-6 和相关指标均有明显改善（P<0.05）。血必净治疗后第3 天和第7 天肝脏功能、心肌酶、凝血指数、动脉血气分析等也改善更明显（P<0.05）。[结论] 血必净注射液治疗复苏后多器官功能障碍综合征可缩短病程，改善症状，防止多器官功能障碍加重。

Abstract:

[Objective] To observe the clinical effect of Xuebingjing injection against multiple organ dysfunction syndrome (MODS) after cardio-pulmonary resuscitation (CPR). [Methods] Using randomly, group-divided method, 98 patients with diagnosed MODS after CPR were assigned as treatment group and control group. The changes of main symptoms, body signs, serum TNF-α, IL-6 and the multiple or-gan function were observed before and after treatment. The control group was treated with normal Western medicine alone while the treat-ment group was with Xuebijing injection and Western medicine. [Results] Compared with the control group, the serum levels of TNF-α and IL-6 of patients in treatment group were more obviously improved (P<0.05). The function of live, myocardial enzymes, coagulation in-dexes and arterial blood gas analysis and so on were also obviously improved after treatment for 3 day and 7 day (P<0.05). [Conclusion] Xuebijing injection can improve symptoms, decurtate course and prevent aggravate of CPR-MODS.