| 摘要: |
| [目的] 观察经支气管镜灌洗痰热清注射液治疗支气管扩张的临床疗效及对气道内中性粒细胞弹性蛋白酶数量的影响.[方法] 将60例支气管扩张症患者随机分为治疗组31例和对照组29例,对照组在常规基础治疗上加用生理盐水进行肺泡灌洗,治疗组在对照组基础上加用痰热清注射液灌洗,观察两组临床疗效及灌洗液中性粒细胞弹性蛋白酶的变化.[结果] 两组总有效率分别为64.5%,65.5%,差异无统计学意义(P>0.05).两组患者治疗前后中性粒细胞弹性蛋白酶的OD值及浓度值差值自身比较,差异有统计学意义(P<0.05);两组患者治疗后中性粒细胞弹性蛋白酶的OD值及浓度值下降,差异有统计学意义(P<0.05).[结论] 经支气管镜灌洗痰热清注射液能改善患者临床症状,明显减少支气管扩张患者气道内中性粒细胞弹性蛋白酶的数量. |
| 关键词: 支气管扩张症 痰热清注射液 支气管肺泡灌洗 中性粒细胞弹性蛋白酶 |
| DOI：10.11656/j.issn.1672-1519.2014.12.05 |
| 分类号: |
| 基金项目:天津市卫生局科研专项课题(1070687). |
|
| Clinical trial on Tanreqing injection in treating bronchiectasis through bronchoalveolar lavage |
|
ZHU Zhen-gang, YUAN Chen, LIU Gui-ying
|
|
Department of Respiratory, The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
|
| Abstract: |
| [Objective] To observe the clinical efficacy and influence of Tanreqing injection on neutrophil elastase(NE) in treating bronchiectasis through bronchoalveolar lavage. [Methods] The 60 cases of bronchiectasis were randomly divided into control group and treatment group. The control group received basic conventional treatment and combined with bronchoscopy alveolar lavage treatment, the treatment group received control group's treatment and combined with Tanreqing injection through bronchoalveolar lavage. The clinical efficacy and changes of NE were evaluated. [Results] The overall effective rate of two group were 64.5% and 65.5%respectively without statistical difference (P>0.05). The value of OD and density was decreased after treatment, with a statistical difference (P>0.05). Comparing with the value of OD and density between two groups before and after treatment, there was a statistical difference (P<0.05). [Conclusion] Tanreqing injection can improve the clinical symptom of patients with bronchiectasis and decrease the number of NE in the airway after bronchoalveolar lavage. |
| Key words: bronchiectasis Tanreqing injection bronchoalveolar lavage neutrophil elastase |
