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乙型肝炎肝硬化患者中医证型与血清NPY的相关性研究
姜付泉1, 薛晓琳1, 王天芳1, 吴秀艳1, 葛舰1, 田露1, 李昕1, 赵丰润1, 赵丽红1, 王思颖1, 李宁1, 李婷婷1, 李永纲2, 杨慧银2, 孙凤霞3, 江宇泳3, 刘燕玲4, 郭朋4, 陈盛铎5, 张秋云6, 李秀惠7, 毛德文8, 张厂9, 刘汶10
1.北京中医药大学基础医学院, 北京 100029;2.解放军第 302 医院中西医结合肝病诊疗与研究中心, 北京 100039;3.首都医科大学附属北京地坛医院, 北京 100011;4.中国中医科学院西苑医院, 北京 100091;5.湖北省中医院, 武汉 430061;6.首都医科大学, 北京 100013;7.首都医科大学附属北京佑安医院, 北京 100052;8.广西中医药大学第一附属医院, 南宁 530023;9.北京中医药大学东方医院, 北京 100078;10.首都医科大学附属北京中医医院, 北京 100010
摘要:
[目的] 探讨乙型肝炎肝硬化患者的中医证型与血清神经肽(NPY)水平的相关性.[方法] 比较代偿期与失代偿期患者的血清NPY值;规范医生对乙型肝炎肝硬化患者的辨证结果,分别选取代偿期与失代偿期中出现频次高的前5个证候并比较不同证候间的血清NPY值.运用SPSS18.0统计软件包进行统计分析.[结果] 代偿期和失代偿期乙型肝炎肝硬化患者血清NPY水平的分别为119.135 0、72.860 0,且差异有统计学意义(P<0.05).血清NPY水平在代偿期各证型之间差异有统计学意义,且肝郁脾虚组>气滞血瘀组>湿热蕴结组>肝肾阴虚组>肝气郁结组;在失代偿期五组之间差异无统计学意义.[结论] 血清NPY水平与疾病的进展有关,与代偿期乙型肝炎肝硬化的中医证型有关.
关键词:  乙型肝炎肝硬化  中医证型  单一证候  血清NPY
DOI:10.11656/j.issn.1672-1519.2015.01.04
分类号:
基金项目:国家自然科学青年基金资助项目(81302915);国家重点基础研究发展计划(973计划)项目(2011CB505105);北京中医药大学创新团队项目(2011CXTD08).
Hepatitis B patients with cirrhosis of traditional Chinese medicine syndrome and thecorrelation of serum NPY research
JIANG Fu-quan1, XUE Xiao-lin1, WANG Tian-fang1, WU Xiu-yan1, GE Jian1, TIAN Lu1, LI Xin1, ZHAO Feng-run1, ZHAO LI-hong1, WANG Si-ying1, LI Ning1, LI Ting-ting1, LI Yong-gang2, YANG Hui-yin2, SUN Feng-xia3, JIANG Yu-yong3, LIU Yan-ling4, GUO Peng4, CHEN Sheng-duo5, ZHANG Qiu-yun6, LI Xiu-hui7, MAO De-wen8, ZHANG Chang9, LIU Wen10
1.School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;2.Liver Disease Center for Combined Traditnonal Chinese Medicine and Western Medicine, 302 Hospital of PLA, Beijing 100039, China;3.Beijing Ditan Hospital Affiated Capital Medical University, Beijing 100011, China;4.Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091, China;5.Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China;6.Capital Medical University, Beijing 100013, China;7.Beijing YouAn Hospital Affiliated to Capital Medical University, Beijing 100052, China;8.The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530023, China;9.Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China;10.Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University, Beijing 100010, China
Abstract:
[Objective] To investigate the hepatitis B patients with cirrhosis of traditional Chinese medicine(TCM) syndrome and the correlation of serum NPY levels. [Methods] Compare compensation period and decompensation period in patients with serum NPY value. Doctor specification of syndrome differentiation in patients with hepatitis B cirrhosis of the liver as a result, the compensation period and decompensation period appear respectively selected high frequency of the first five syndromes and compare the value of serum NPY between different syndrome. Using the SPSS18.0 statistical software package for statistical analysis. [Results] Compensation period and decompensation period NPY levels in the serum of patients with hepatitis B cirrhosis of the liver were 119.135 0, 72.910 0, and the difference was statistically significant (P < 0.05). Serum NPY level in compensatory phase difference was statistically significant among different syndrome types, and stagnation of liver Qi and spleen deficiency group > Qi and blood stasis group > damp and hot accumulate knot > liver-kidney Yin deficiency group > move within group. In decompensated period there was no statistically significant difference between groups of five. [Conclusion] Serum NPY levels associated with disease progression, and the compensatory phase of hepatitis B cirrhosis related to the TCM syndrome type.
Key words:  hepatitis B cirrhosis of the liver  syndrome of traditional Chinese medicine  a single syndrome  serum NPY
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