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| 银杏叶提取物对家兔高胆固醇血症模型脑组织形态学的影响 |
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高青1, 马东明1, 胡先同1, 卢斌1, 张瑞峰2, 冯玉陶3, 姜希娟1
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1.天津中医药大学中西医结合学院, 天津 300193;2.新泰市中医院病理科, 新泰 271200;3.天津武警后勤学院附属医院中医科, 天津 300162
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| 摘要: |
| [目的] 通过高胆固醇血症家兔模型观察银杏叶提取物(EGB761)对中枢神经纤维的影响。[方法] 以成年雄性新西兰大白兔复制高胆固醇血症模型,实验分为4组：对照组、模型组、阳性药辛伐他汀组、EGB761组。用苏木精-伊红(HE)染色和嗜银染色法观察神经元及神经纤维的形态学改变。[结果] 外周胆固醇升高时,模型组海马出现较多神经元变性、坏死,神经纤维缠结等病理改变。EGB761组变性、坏死的神经元明显少于模型组,细胞核形态基本规则,嗜神经现象少见,神经纤维缠结少于模型组。[结论] EGB761可有效保护高胆固醇血症时神经纤维结构的完整性。 |
| 关键词: 银杏叶提取物 高胆固醇血症 神经纤维 |
| DOI：10.11656/j.issn.1672-1519.2015.03.09 |
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| 基金项目:高校博士点专项基金资助项目(20101210120008). |
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| Effect of the extract of Ginkgo Biloba in brain tissue morphology in rabbit hypercholesteremia model |
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GAO Qing1, MA Dong-ming1, HU Xian-tong1, LU Bin1, ZHANG Rui-feng2, FENG Yu-tao3, JIANG Xi-juan1
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1.School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Department of Pathology, Xintai Hospital of Traditional Chinese Medicine, Xintai 271200, China;3.Department of Traditional Chinese Medicine, Affiliated Hospital of Tianjin Armed Police Logistics College, Tianjin 300162, China
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| Abstract: |
| [Objective] To study the effect of the extract of Ginkgo Biloba 761(EGB 761) on brain tissue morphology in rabbit hypercholesteremia model. [Methods] We built the hypercholesteremia model with male New Zealand white rabbits, which were divided into four groups: the control group, the model group, the simvastatin group, the EGB761 group. Detecting the morphology change of nerve fiber with HE staining and silver staining. [Results] The hippocampus in model group showed neuronal degeneration, necrosis and microfibers tangles while the EGB761 group showed less neuronal degeneration, necrosis and microfibers tangles, and regular nuclear morphometry. [Conclusion] EGB761 can effectively protect the integrity of the structure of nerve fibers in hypercholesterolemia. |
| Key words: extract of Ginkgo Biloba hypercholesteremia nerve fiber |
