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| 中药逆转MCF-7/ADM细胞多药耐药机制的研究进展 |
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曾青青1,2, 王鹏1,2, 潘桂湘1, 王晓明1, 王春华1
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1.天津中医药大学, 天津市现代重点实验室-省部共建国家重点实验室培育基地, 天津 300193;2.天津国际生物医药联合研究院, 天津 300457
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| 摘要: |
| 乳腺癌细胞(MCF-7/ADM)的多药耐药性(MDR)是导致抗肿瘤药物临床化疗失败的主要原因。现认为细胞中的P-gp、Bcl-2、GST-π、TopoⅡ等蛋白可能与乳腺癌的多药耐药相关。近年来研究发现,不少中药能够下调MDR1 mRNA和/或P-gp的表达,从而逆转MCF-7/ADM细胞对抗肿瘤药物的多药耐药性,提高耐药细胞对化疗药物敏感性。主要对MCF-7/ADM细胞的多药耐药机制及有逆转MCF-7/ADM多药耐药作用的中药进行了综述。 |
| 关键词: 中药 MCF-7/ADM 多药耐药 P-gp |
| DOI：10.11656/j.issn.1672-1519.2015.04.15 |
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| 基金项目:国家自然科学基金项目(81001633, 81173523, 81303182);天津市自然基金项目(13JCZDJC28600). |
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| Development in reversing mechanism of MCF-7/ADM cell multidrug resistance by traditional Chinese medicine |
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ZENG Qing-qing1,2, WANG Peng1,2, PAN Gui-xiang1, WANG Xiao-ming1, WANG Chun-hua1
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1.Modern Key Laboratory in Tianjin, Key Laboratory Breeding Base of State Constructed by Provincial Department, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China
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| Abstract: |
| Chemotherapy failure of antitumor drugs in clinical was mainly caused by multidrug resistance (MDR) of breast cancer cells (MCF-7/ADM). P-gp、Bcl-2、GST-π、TopoⅡand other proteins may be associated with the multi-drug resistance of breast cancer. In recent years, many traditional Chinese medicine were found that they can reduce the expression of MDR1 mRNA and/or P-gp protein, thereby reversing the multi-drug resistance of tumor drugs against human breast cancer cells and increase their chemosensitivity to chemotherapeutic drugs. Therefore, the summary is about resistance mechanisms of MCF-7/ADM and traditional Chinese medicines which can reverse multi-drug resistance of breast cancer cells. |
| Key words: traditional Chinese medicine MCF-7/ADM cell multidrug resistance P-gp |
