| 摘要: |
| [目的] 研究参麦注射液对心肌梗死大鼠的心肌保护作用。[方法] 采用结扎冠状动脉前降支制备大鼠心肌梗死模型。利用超声心动和血流多普勒分析进行心功能的评价;生化分析测定血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)及丙二醛(MDA)的水平;并结合苏木精- 伊红(HE)染色病理学分析,综合评价参麦注射液心肌梗死的保护作用。[结果] 参麦注射液能显著改善心肌梗死后左室心功能和心脏供血功能,降低血清CK、CK-MB、LDH和MDA 水平,增加SOD活力,同时,降低心肌组织病变程度,包括减少炎性浸润,减少心肌纤维化。[结论] 综合评价参麦注射液对心肌梗死大鼠的心肌有保护作用。 |
| 关键词: 参麦注射液 心肌梗死 心肌保护 |
| DOI：10.11656/j.issn.1672-1519.2015.06.08 |
| 分类号: |
| 基金项目:国家重点基础研究发展计划(973计划)资助项目(2012CB518404)。 |
|
| Myocardial protection of Shenmai injection on acute myocardial infarction in rats |
|
ZHU Li-jie, CHEN Jing-rui, GONG Bo, FAN Guan-wei
|
|
Research Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
|
| Abstract: |
| [Objective] To study the protective effect of Shenmai injection on myocardial infarction of rats. [Methods] Construction of rat myocardial infarction model using coronary artery ligation. Detected by echocardiography and Doppler blood flow, determination of serum creatine kinase(CK), creatine kinase(CK-MB), lactate dehydrogenase (LDH), superoxide dismutase(SOD) and malondialdehyde(MDA) activity change; combined with HE staining Pathological analysis, comprehensive evaluation of the protective effect of Shenmai injection on myocardial infarction. [Results] Shenmai injection can significantly improve left ventricular function and cardiac blood supply function after myocardial infarction, reducing myocardial tissue lesions, including the reduction of inflammatory infiltration, reduction of myocardial fibrosis, and reduce CK, LDH, MDA levels, increase the activity of SOD. [Conclusion] Shenmai injection has a protective effect on myocardial infarction of rats. |
| Key words: Shenmai injection myocardial infarction myocardial protection |
