| 摘要: |
| [目的] 研究牛磺酸纳米乳的处方、制备及稳定性考察。[方法] 通过滴定法绘制伪三元相图,根据相图优选处方,并初步考察牛磺酸纳米乳的稳定性、粒径分布和理化性质。[结果] 确定纳米乳处方为十四酸异丙酯(IPM):司盘-80:吐温-80:水=4:4:6:1.牛磺酸纳米乳平均粒径为30.8 nm.[结论] 牛磺酸纳米乳制备方法简单,性质稳定。 |
| 关键词: 牛磺酸 纳米乳 伪三元相图 稳定性 |
| DOI：10.11656/j.issn.1672-1519.2015.06.14 |
| 分类号: |
| 基金项目:天津市卫生局科技基金项目(05kyz02)。 |
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| Preparation and stability of taurine nanoemulsion |
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LI Zhen-hua1, LI Xiang1, ZHAO Zhen-yu1, ZHANG Yun-hui2
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1.Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China;2.School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
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| Abstract: |
| [Objective] To study the optimum formulation and preparation and stability of taurine nanoemulsion. [Methods] The optimum formulation was investigated by using titration to prepare the pseudo-ternary phase diagram, testing the size distribution,stability and physico-chemical property of taurine nanoemulsion. [Results] The optimum formulation was IPM:Span80:Tween80:water=4:4:6:1.The stability of taurine nanoemulsion was good, and average size was 30.8 nm.[Conclusion] Taurine nanoemulsion is easy to prepare and has good stability. |
| Key words: taurine nanoemulsion pseudo-ternary phase diagram stability |
